Trial reportJournal of perinatology : official journal of the California Perinatal Association2005
Work of breathing during nasal continuous positive airway pressure in preterm infants: a comparison of bubble vs variable-flow devices.
Trial report in Journal of perinatology : official journal of the California Perinatal Association, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 15 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Choice and Optimal Settings of Non Invasive Respiratory Support in Preterm Newborns < 30 Gestational Weeks
Feasibility and Acceptability Followed by Effectiveness of Bubble Continuous Positive Airway Pressure (bCPAP) for Treatment of Children Aged 1-59 Months With Severe Pneumonia in Ethiopia: A Cluster Randomized Controlled Clinical Trial
Who cites it
15 citing papers in PubMed, 1 synthesis or guideline pooled it, 101 citations in OpenAlex.
- Devices and pressure sources for administration of nasal continuous positive airway pressure (NCPAP) in preterm neonates.The Cochrane database of systematic reviews · 2008Pooled it
- Trial
- Nasal Jet-CPAP (variable flow) versus Bubble-CPAP in preterm infants with respiratory distress: an open label, randomized controlled trial.Journal of perinatology : official journal of the California Perinatal Association · 2015Trial
- Bubble and ventilator-derived nasal continuous positive airway pressure in premature infants: work of breathing and gas exchange.Journal of perinatology : official journal of the California Perinatal Association · 2011Trial
- Nasal continuous positive airway pressure from high flow cannula versus Infant Flow for Preterm infants.Journal of perinatology : official journal of the California Perinatal Association · 2006Trial
- Imposed work of breathing of 16 neonatal CPAP-devices using different mechanisms of CPAP generation.Pediatric research · 2026Article
- Bubble devices versus other pressure sources for nasal continuous positive airway pressure in preterm infants.The Cochrane database of systematic reviews · 2023Review
- Effectiveness of Bubble Continuous Positive Airway Pressure (BCPAP) for Treatment of Children Aged 1-59 Months with Severe Pneumonia and Hypoxemia in Ethiopia: AJournal of clinical medicine · 2022Article
- Use of Nasal Bubble CPAP in Children with Hypoxemic Clinical Pneumonia-Report from a Resource Limited Set-Up.Journal of tropical pediatrics · 2016Article
- Weaning preterm infants from continuous positive airway pressure: evidence for best practice.World journal of pediatrics : WJP · 2015Review
- Intra-gastric pressures in neonates receiving bubble CPAP.Indian journal of pediatrics · 2015Article
- Safety and effectiveness of bubble continuous positive airway pressure in preterm neonates with respiratory distress.Medical journal, Armed Forces India · 2014Article
- CPAP review.European journal of pediatrics · 2012Review
- Bubble continuous positive airway pressure enhances lung volume and gas exchange in preterm lambs.American journal of respiratory and critical care medicine · 2007Article
- Early variable-flow nasal continuous positive airway pressure in infants < or =1000 grams at birth.Journal of perinatology : official journal of the California Perinatal Association · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare work of breathing and breathing asynchrony during bubble nasal continuous positive airway pressure (NCPAP) vs variable-flow (VF)-NCPAP in premature infants. STUDY
designWe studied 18 premature infants of birth weight <1500 g who required NCPAP for mild respiratory distress. Each infant was studied on bubble and VF-NCPAP at 8, 6, 4, and 0 cm H2O. Tidal volumes were obtained by calibrated respiratory inductance plethysmography. Esophageal pressure estimated intrapleural pressure. Inspiratory and resistive work of breathing were calculated from pressure-volume data. Breathing asynchrony was assessed with phase angle. The results at all NCPAP levels were referenced to VF-NCPAP values at 8 cm H2O.
resultsProvision of NCPAP with either device decreased inspiratory work of breathing, tidal volume, and minute ventilation relative to NCPAP of 0 cm H2O. Bubble NCPAP did not decrease resistive work of breathing relative to 0 cm H2O. Resistive work of breathing (p=0.01), respiratory rate (p<0.03), and phase angle (p=0.002) were all greater with bubble compared to VF-NCPAP.
conclusionThe more labored and asynchronous breathing seen with bubble NCPAP may lead to higher failure rates over the long term than with VF-NCPAP.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.