ArticleJournal of clinical pathology2005
Processing of radical prostatectomy specimens for correlation of data from histopathological, molecular biological, and radiological studies: a new whole organ technique.
Article in Journal of clinical pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Optimal liquid-based DNA preservation for DNA barcoding of field-collected fungal specimens.Heliyon · 2024Article
- Ex Vivo Fluorescence Confocal Microscopy (FCM) Ensures Representative Tissue in Prostate Cancer Biobanking: A Feasibility Study.International journal of molecular sciences · 2022Article
- Three-Dimensional Printed Molds for Image-Guided Surgical Biopsies: An Open Source Computational Platform.JCO clinical cancer informatics · 2020Article
- Liver-specific 3D sectioning molds for correlating in vivo CT and MRI with tumor histopathology in woodchucks (Marmota monax).PloS one · 2020Article
- Article
- MR Imaging-Histology Correlation by Tailored 3D-Printed Slicer in Oncological Assessment.Contrast media & molecular imaging · 2019Review
- Volumetry of the dominant intraprostatic tumour lesion: intersequence and interobserver differences on multiparametric MRI.The British journal of radiology · 2017Article
- Customized Tool for the Validation of Optical Coherence Tomography in Differentiation of Prostate Cancer.Technology in cancer research & treatment · 2017Article
- Multivariate modelling of prostate cancer combining magnetic resonance derived T2, diffusion, dynamic contrast-enhanced and spectroscopic parameters.European radiology · 2015Article
- Ceramic foam plates: a new tool for processing fresh radical prostatectomy specimens.Virchows Archiv : an international journal of pathology · 2014Article
- Decision support system for localizing prostate cancer based on multiparametric magnetic resonance imaging.Medical physics · 2012Article
- Next-generation prostate cancer biobanking: toward a processing protocol amenable for the International Cancer Genome Consortium.Diagnostic molecular pathology : the American journal of surgical pathology, part B · 2012Article
- Use of patient-specific MRI-based prostate mold for validation of multiparametric MRI in localization of prostate cancer.Urology · 2012Article
- A decade in prostate cancer: from NMR to metabolomics.Nature reviews. Urology · 2011Review
- Optimum slicing of radical prostatectomy specimens for correlation between histopathology and medical images.International journal of computer assisted radiology and surgery · 2010Review
- A method for correlating in vivo prostate magnetic resonance imaging and histopathology using individualized magnetic resonance-based molds.The Review of scientific instruments · 2009Article
- Molecular markers in prostate cancer. Part I: predicting lethality.Asian journal of andrology · 2009Review
- Complex patterns of ETS gene alteration arise during cancer development in the human prostate.Oncogene · 2008Article
- Detection of TMPRSS2-ERG translocations in human prostate cancer by expression profiling using GeneChip Human Exon 1.0 ST arrays.The Journal of molecular diagnostics : JMD · 2008Article
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Corrections and comments
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Authors and funding
17 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo develop a method of processing non-formalin fixed prostate specimens removed at radical prostatectomy to obtain fresh tissue for research and for correlating diagnostic and molecular results with preoperative imaging. METHODS/
resultsThe method involves a prostate slicing apparatus comprising a tissue slicer with a series of juxtaposed planar stainless steel blades linked to a support, and a cradle adapted to grip the tissue sample and receive the blades. The fresh prostate gland is held in the cradle and the blades are moved through the cradle slits to produce multiple 4 mm slices of the gland in a plane perpendicular to its posterior surface. One of the resulting slices is preserved in RNAlater. The areas comprising tumour and normal glands within this preserved slice can be identified by matching it to the haematoxylin and eosin stained sections of the adjacent slices that are formalin fixed and paraffin wax embedded. Intact RNA can be extracted from the identified tumour and normal glands within the RNAlater preserved slice. Preoperative imaging studies are acquired with the angulation of axial images chosen to be similar to the slicing axis, such that stained sections from the formalin fixed, paraffin wax embedded slices match their counterparts on imaging.
conclusionsA novel method of sampling fresh prostate removed at radical prostatectomy that allows tissue samples to be used both for diagnosis and molecular analysis is described. This method also allows the integration of preoperative imaging data with histopathological and molecular data obtained from the prostate tissue slices.
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