Evidence map›Paper›PMID 15858049›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005

Nerve growth factor rapidly increases muscarinic tone in mouse medial septum/diagonal band of Broca.

Chia-wen K Wu, Hermes H Yeh

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
0.4field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Functional Diversity of Neurotrophin Actions on the Oculomotor System.International journal of molecular sciences · 2016
    Review
  8. Review
  9. Article
  10. Article
  11. The beneficial role of vitamin D in Alzheimer's disease.American journal of Alzheimer's disease and other dementias · 2011
    Review
  12. Nerve growth factor regulates the firing patterns and synaptic composition of motoneurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010
    Article
  13. Article
  14. p75 and TrkA signaling regulates sympathetic neuronal firing patterns via differential modulation of voltage-gated currents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009
    Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Chia-wen K WuCenter for Aging and Developmental Biology, Department of Pharmacology and Physiology, University of Rochester Medical Center, Rochester, New York 14642, USA.
Hermes H Yeh
University of Rochester Medical Center · US

Funding

The Septohippocampal System: Regulation by NeurotrophinsR01NS048603 · NINDS · UNIVERSITY OF ROCHESTER · PI YEH, HERMES H · 2004 to 2008
$1.8M
Ethanol Consumption and Muscarinic Tone in Medial SeptumR01AA014698 · NIAAA · UNIVERSITY OF ROCHESTER · PI YEH, HERMES H · 2004 to 2008
$1.7M
NIAAA NIH HHS R01 AA014698NINDS NIH HHS R01 NS048603
6 · The paper itself

Abstract

Nerve growth factor (NGF) has been implicated in maintaining and regulating normal functioning of the septohippocampal pathway. However, many aspects of its physiological actions and the underlying mechanisms await elucidation. In this study, we investigated the effect of acute NGF exposure on neurons in the mouse medial septum/diagonal band of Broca (MS/DB), focusing on the cholinergic neurons and the subpopulation of noncholinergic neurons that were identified to be putatively GABAergic. We report that MS/DB neurons in a thin slice preparation, when exposed to NGF via bath perfusion, rapidly and indiscriminately increased the rate of spontaneous firing in all MS/DB neurons. However, focal application of NGF to individual MS/DB neurons increased spontaneous firing in cholinergic, but not in the noncholinergic, subpopulation. The NGF-induced effect on cholinergic neurons was direct, requiring activation and signaling via TrkA receptors, which were immunohistochemically localized to the cholinergic neurons in the MS/DB. TrkA receptors were absent in putative GABAergic MS/DB neurons, and blockade of TrkA signaling in these and other noncholinergic neurons had no effect on their firing activity after exposure to NGF. Conversely, methyl scopolamine, blocked the increased firing activity of noncholinergic neurons during bath perfusion of NGF. We propose a cell type-specific mode of action for NGF in the MS/DB. The neurotrophin directly enhances cholinergic neuronal activity in the MS/DB through TrkA-mediated signaling, increasing acetylcholine release and, thus, muscarinic tone. This increase in muscarinic tone, in turn, results in heightened firing activity in noncholinergic MS/DB neurons.

Indexed as

Action PotentialsAnimalsAnimals, NewbornBlotting, WesternCalbindin 2CalbindinsCarbazolesCholine O-AcetyltransferaseCholinesterase InhibitorsDiagonal Band of BrocaDose-Response Relationship, DrugDrug InteractionsElectric StimulationEnzyme InhibitorsFluorescent Antibody TechniqueIndole AlkaloidsCalbindin 2CalbindinsCarbazolesCholine O-AcetyltransferaseCholinesterase InhibitorsEnzyme InhibitorsIndole AlkaloidsMuscarineMuscarinic AntagonistsNeostigmineNerve Growth FactorsParvalbuminsReceptor, Nerve Growth FactorReceptor, trkAReceptor, trkBS100 Calcium Binding Protein GScopolaminestaurosporine aglycone

Identifiers

PMID15858049
PMCPMC6725107
OpenAlexW2012709588

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.