Evidence map›Paper›PMID 15858033›Full record

ArticleJournal of virology2005

Human circovirus TT virus genotype 6 expresses six proteins following transfection of a full-length clone.

Jianming Qiu, Laura Kakkola, Fang Cheng, Chaoyang Ye, Maria Söderlund-Venermo, Klaus Hedman, David J Pintel

Open access · greenAbstract read
In one paragraph

Article in Journal of virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
10.1field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 71 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
  5. Nuclear trafficking ofVirus evolution · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Jianming QiuDepartment of Molecular Microbiology and Immunology, University of Missouri-Columbia, School of Medicine, Columbia, MO 65212, USA. qiuj@missouri.edu
Laura Kakkola
Fang Cheng
Chaoyang Ye
Maria Söderlund-Venermo
Klaus Hedman
David J Pintel
University of Helsinki · FIUniversity of Missouri · USHelsinki University Hospital · FI

Funding

Parvovirus RNA Processing and Gene Expression StrategiesR01AI046458 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI PINTEL, DAVID J. · 2000 to 2018
$4.6M
Adeno-associated Virus RNA Splicing and PolyadenylationR01AI056310 · NIAID · UNIVERSITY OF MISSOURI-COLUMBIA · PI PINTEL, DAVID J. · 2004 to 2013
$3.4M
NIAID NIH HHS AI 56310NIAID NIH HHS R01 AI046458NIAID NIH HHS R01 AI056310NIAID NIH HHS R01 AI 46458
6 · The paper itself

Abstract

The expression profile of the circovirus TTV has not yet been fully characterized. In this paper, we show that following transfection of a full-length viral clone of TTV genotype 6, each of the three virally encoded mRNAs is translated from two initiating AUGs, and therefore, the TTV genome generates at least six proteins. Localization studies of hemagglutinin-tagged versions of these proteins in fixed cells, and green fluorescent protein-tagged versions of these proteins in living cells, expressed following transfection, demonstrated that two were primarily nuclear, two were primarily cytoplasmic, and two were found throughout the cell.

Indexed as

Cell LineCell NucleusCytoplasmHumansMolecular Sequence DataTorque teno virusTransfectionViral ProteinsViral Proteins

Identifiers

PMID15858033
PMCPMC1091685
OpenAlexW2166994772

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.