ArticleJournal of anatomy2005
Endoplasmic reticulum positioning and partitioning in mitotic HeLa cells.
Article in Journal of anatomy, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
32 citing papers in PubMed, 51 citations in OpenAlex.
- Mitochondria-ER contact sites expand during mitosis.iScience · 2024Article
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- Organelle Communication with the Nucleus.Results and problems in cell differentiation · 2024Review
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- A tubule-sheet continuum model for the mechanism of nuclear envelope assembly.Developmental cell · 2023Article
- The hypervariable region of atlastin-1 is a site for intrinsic and extrinsic regulation.The Journal of cell biology · 2021Article
- Remodeling of ER-plasma membrane contact sites but not STIM1 phosphorylation inhibits CaProceedings of the National Academy of Sciences of the United States of America · 2019Article
- Article
- The endoplasmic reticulum is partitioned asymmetrically during mitosis before cell fate selection in proneuronal cells in the earlyMolecular biology of the cell · 2017Article
- The endoplasmic reticulum: structure, function and response to cellular signaling.Cellular and molecular life sciences : CMLS · 2016Review
- Cell Cycle-dependent Changes in Localization and Phosphorylation of the Plasma Membrane Kv2.1 K+ Channel Impact Endoplasmic Reticulum Membrane Contact Sites in COS-1 Cells.The Journal of biological chemistry · 2015Article
- An organelle-exclusion envelope assists mitosis and underlies distinct molecular crowding in the spindle region.The Journal of cell biology · 2015Article
- From gross anatomy to the nanomorphome: stereological tools provide a paradigm for advancing research in quantitative morphomics.Journal of anatomy · 2015Article
- Strategies for maximizing ATP supply in the microsporidian Encephalitozoon cuniculi: direct binding of mitochondria to the parasitophorous vacuole and clustering of the mitochondrial porin VDAC.Cellular microbiology · 2014Article
- Reticulon 4 is necessary for endoplasmic reticulum tubulation, STIM1-Orai1 coupling, and store-operated calcium entry.The Journal of biological chemistry · 2014Article
- Endoplasmic reticulum structure and interconnections with other organelles.Cold Spring Harbor perspectives in biology · 2013Review
- A novel carboxyl-terminal heptapeptide initiates the regulated secretion of LH from unique sub-domains of the ER.PloS one · 2013Article
- Progressive sheet-to-tubule transformation is a general mechanism for endoplasmic reticulum partitioning in dividing mammalian cells.Molecular biology of the cell · 2012Article
- A 3D analysis of yeast ER structure reveals how ER domains are organized by membrane curvature.The Journal of cell biology · 2011Article
- Oocyte-targeted deletion reveals that hsp90b1 is needed for the completion of first mitosis in mouse zygotes.PloS one · 2011Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Cell division serves to distribute chromosomes and organelles into two daughter cells, but the mechanism of rough endoplasmic reticulum (RER) segregation in animal cell mitosis is poorly understood. Here we study the distribution of RER in mitotic HeLa cells and its relation to the cytoskeleton. At metaphase, the RER was located in the cell cortex and was most concentrated in two locations. Close to the plasma membrane the RER was closely associated with cortical actin, and after treatment with Latrunculin A RER elements retracted to the deep cortex and became more tubular. Positioning was therefore dependent on cortical F-actin. Deeper in the cortex cisternae were wrapped tightly around the contours of the spindle body and orientated along microtubules close the spindle poles. Stereology revealed a close correlation between RER volume and cell volume in telophase daughter cells. These results suggest that the RER is positioned at the outer and inner regions of metaphase cortex by association with cytoskeleton. This arrangement combined with a disposition in concentric layers, deep to the plasma membrane, appears to distribute the RER evenly in the cortex and may help to couple quantities of RER and cell constituents.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.