ArticleLasers in surgery and medicine2005
Studies of a vascular-acting photosensitizer, Pd-bacteriopheophorbide (Tookad), in normal canine prostate and spontaneous canine prostate cancer.
Article in Lasers in surgery and medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 74 citations in OpenAlex.
- A Synergistic Strategy Combining Chemotherapy and Photodynamic Therapy to Eradicate Prostate Cancer.International journal of molecular sciences · 2024Article
- Review
- Photodynamic Diagnosis and Therapy for Peritoneal Carcinomatosis from Gastrointestinal Cancers: Status, Opportunities, and Challenges.Journal of gastric cancer · 2020Review
- Article
- A promising anticancer drug: a photosensitizer based on the porphyrin skeleton.RSC medicinal chemistry · 2020Review
- Photosensitizers in prostate cancer therapy.Oncotarget · 2017Review
- Vascular targeted photochemotherapy using padoporfin and padeliporfin as a method of the focal treatment of localised prostate cancer - clinician's insight.World journal of methodology · 2016Review
- Myocardial necrosis depth prediction during extracellular photosensitization reaction of talaporfin sodium by defined index using fluorescence measurement.Lasers in medical science · 2014Article
- Focal therapy in the management of prostate cancer: an emerging approach for localized prostate cancer.Advances in urology · 2012Article
- Neuropilin-1 targeting photosensitization-induced early stages of thrombosis via tissue factor release.Pharmaceutical research · 2010Article
- Effect of drug-light interval on the mode of action of Photofrin photodynamic therapy in a mouse tumor model.Lasers in medical science · 2009Article
- Photodynamic therapy for treatment of solid tumors--potential and technical challenges.Technology in cancer research & treatment · 2008Review
- A pilot trial of vascular targeted photodynamic therapy for renal tissue.The Journal of urology · 2008Article
- Combination of photodynamic therapy and immunomodulation: current status and future trends.Medicinal research reviews · 2008Review
- The effect of Tookad-mediated photodynamic ablation of the prostate gland on adjacent tissues--in vivo study in a canine model.Photochemical & photobiological sciences : Official journal of the European Photochemistry Association and the European Society for Photobiology · 2007Article
- The future of lasers in urology.World journal of urology · 2007Review
- Magnetic resonance imaging correlated with the histopathological effect of Pd-bacteriopheophorbide (Tookad) photodynamic therapy on the normal canine prostate gland.Lasers in surgery and medicine · 2006Article
- A review of progress in clinical photodynamic therapy.Technology in cancer research & treatment · 2005Review
- Effects of photodynamic therapy on peripheral nerve: in situ compound-action potentials study in a canine model.Photomedicine and laser surgery · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectivesPhotodynamic therapy (PDT) mediated with Tookad (Pd-bacteriopheophorbide, WST09) was investigated pre-clinically as part of a program to develop an alternative modality for treating prostate cancer. STUDY DESIGN/MATERIALS AND
methodsSpontaneous canine prostate cancer and normal canine prostate were used as the animal models. Interstitial PDT was performed by IV infusion of the photosensitizer and irradiating the prostates with a diode laser (763 nm). The prostates were harvested 1-week post-PDT and subjected to histopathologic examinations. The effects of the drug doses and light doses were studied for one- and two-session PDT. Pharmacokinetics were studied using HPLC assay. The feasibility of using perfusing CT scans for assessing PDT lesions was also evaluated.
resultsTookad is a vascular-acting drug and clears rapidly from the circulation. Tookad-PDT-induced lesions, in both normal and cancerous prostates, were characterized by marked hemorrhagic necrosis.
conclusionsTookad-PDT is very effective in ablating prostatic tissue through its vascular effects.
Indexed as
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.