ReviewNaunyn-Schmiedeberg's archives of pharmacology2005
Transcriptional regulation and processing increase the functional variability of TRPM channels.
Review in Naunyn-Schmiedeberg's archives of pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 29 citations in OpenAlex.
- Mutations of TRPM8 channels: Unraveling the molecular basis of activation by cold and ligands.Medicinal research reviews · 2022Review
- The Journey to Discovering a Flatworm Target of Praziquantel: A Long TRP.Trends in parasitology · 2020Review
- Differential epitope masking reveals synapse-specific complexes of TRPM1.Visual neuroscience · 2018Article
- Role of TRP ion channels in cancer and tumorigenesis.Seminars in immunopathology · 2016Review
- Permeation, regulation and control of expression of TRP channels by trace metal ions.Pflugers Archiv : European journal of physiology · 2015Review
- Bidirectional modulation of thermal and chemical sensitivity of TRPM8 channels by the initial region of the N-terminal domain.The Journal of biological chemistry · 2014Article
- Transient receptor potential melastatin 1 (TRPM1) is an ion-conducting plasma membrane channel inhibited by zinc ions.The Journal of biological chemistry · 2011Article
- Pharmacological and functional properties of TRPM8 channels in prostate tumor cells.Pflugers Archiv : European journal of physiology · 2011Article
- Transient receptor potential (TRP) channels as drug targets.Naunyn-Schmiedeberg's archives of pharmacology · 2006Article
- TRP channels as new pharmacological targets.Naunyn-Schmiedeberg's archives of pharmacology · 2005Article
- Regulation of TRPM2 channels in neutrophil granulocytes by ADP-ribose: a promising pharmacological target.Naunyn-Schmiedeberg's archives of pharmacology · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mammalian TRP channels display heterogenous biophysical properties and are involved in a variety of signal transduction pathways. To carry out their diverse biological functions and to adapt these functions to changes of the environment, mechanisms to regulate their molecular structure are required. Transcriptional regulation and post-transcriptional RNA processing represent essential instruments to generate TRP channel variants with modified properties. TRP variants are expressed depending on the tissue and developmental state. They can show distinct biophysical properties and mechanisms of activation, and thereby determine channel function and malfunction in certain human diseases. In this review, we give an overview of the variants of a given TRP gene, with the focus on the TRPM subfamily, and discuss their relevance with respect to their function under physiological and pathological conditions.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.