ArticleInternational journal of colorectal disease2006
Blocking MAdCAM-1 in vivo reduces leukocyte extravasation and reverses chronic inflammation in experimental colitis.
Article in International journal of colorectal disease, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 55 citations in OpenAlex.
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- Cerebrovascular Senescence Is Associated With Tau Pathology in Alzheimer's Disease.Frontiers in neurology · 2020Article
- Anti-MAdCAM-1-Conjugated Nanocarriers Delivering Quantum Dots Enable Specific Imaging of Inflammatory Bowel Disease.International journal of nanomedicine · 2020Article
- A State-of-the-Art Review of New and Emerging Therapies for the Treatment of IBD.Inflammatory bowel diseases · 2019Review
- MAdCAM-1-Mediated Intestinal Lymphocyte Homing Is Critical for the Development of Active Experimental Autoimmune Encephalomyelitis.Frontiers in immunology · 2019Article
- αEβ7 Integrin Identifies Subsets of Pro-Inflammatory Colonic CD4+ T Lymphocytes in Ulcerative Colitis.Journal of Crohn's & colitis · 2017Article
- Mucosal addressin cell adhesion molecule-1 of rhesus macaques: molecular cloning, expression, and alteration after viral infection.Digestive diseases and sciences · 2014Article
- Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease.Clinical and experimental immunology · 2012Article
- Shining a light on intestinal traffic.Clinical & developmental immunology · 2012Review
- Molecular imaging with optical coherence tomography using ligand-conjugated microparticles that detect activated endothelial cells: rational design through target quantification.Atherosclerosis · 2011Article
- Impact of adrenomedullin on dextran sulfate sodium-induced inflammatory colitis in mice: insights from in vitro and in vivo experimental studies.International journal of colorectal disease · 2011Article
- Blocking lymphocyte localization to the gastrointestinal mucosa as a therapeutic strategy for inflammatory bowel diseases.Gastroenterology · 2011Article
- Abscisic acid ameliorates experimental IBD by downregulating cellular adhesion molecule expression and suppressing immune cell infiltration.Clinical nutrition (Edinburgh, Scotland) · 2010Article
- Contribution of bone marrow-derived cells to the pro-inflammatory effects of protease-activated receptor-2 in colitis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2010Article
- Anti-adhesion molecule therapy for inflammatory bowel disease.Therapeutic advances in gastroenterology · 2010Article
- Targeting improves MSC treatment of inflammatory bowel disease.Molecular therapy : the journal of the American Society of Gene Therapy · 2010Article
- Advances in sexually transmitted infections of the gastrointestinal tract.Nature reviews. Gastroenterology & hepatology · 2009Review
- Pharmacological characterization of PF-00547659, an anti-human MAdCAM monoclonal antibody.British journal of pharmacology · 2009Article
Corrections and comments
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Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLeukocyte recruitment to sites of intestinal inflammation is a crucial multi-step process, leading ultimately to the accumulation of cells in the inflamed tissue. These interactions in the gut are critically dependent on the mucosal addressin cell adhesion molecule-1 (MAdCAM-1), which is expressed on endothelial cells within the mesenteric lymph nodes and the lamina propria of the intestine. Here, we investigate the pathophysiologic role of MAdCAM-1 in the intestinal microcirculation in vivo.
methodsUsing a standard mouse model, chronic colitis was established after four cycles of dextran sodium sulfate (DSS) application. MAdCAM-1 expression was investigated by immunohistochemistry and Western blotting, as well as real-time polymerase chain reaction (PCR). Intravital microscopy was used to study the role of MAdCAM-1 on leukocyte-endothelium interactions and leukocyte extravasation.
resultsSignificant changes in MAdCAM-1 were observed in mice with chronic DSS-induced colitis. Upregulation of MAdCAM-1 expression in chronic colitis was demonstrated on a protein and messenger ribonucleic acid (mRNA) level. Anti-MAdCAM-1 treatment lead to a marked reduction (>60%) of leukocyte sticking and extravasation in vivo, compared to the controls. This was parallelled by a significant reduction (45%) of intestinal inflammation, as measured by the histologic grading score.
conclusionThese in vivo results demonstrate a distinct role of MAdCAM-1 in inflammatory intestinal diseases, and suggest that therapeutic strategies targeting this adhesion molecule could be useful in the treatment of chronic colitis.
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