ArticleExperimental brain research2005
Co-induction of alphaB-crystallin and MAPKAPK-2 in astrocytes in the penumbra after transient focal cerebral ischemia.
Article in Experimental brain research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 35 citations in OpenAlex.
- Review
- Crystallin Alpha-B Overexpression as a Possible Marker of Reactive Astrogliosis in Human Cerebral Contusions.Frontiers in cellular neuroscience · 2022Article
- HspB4/αA-Crystallin Modulates Neuroinflammation in the Retina via the Stress-Specific Inflammatory Pathways.Journal of clinical medicine · 2021Article
- Axotomy-Induced Changes of the Protein Profile in the Crayfish Ventral Cord Ganglia.Journal of molecular neuroscience : MN · 2019Article
- Profiling of Signaling Proteins in Penumbra After Focal Photothrombotic Infarct in the Rat Brain Cortex.Molecular neurobiology · 2017Article
- Upregulation and phosphorylation of HspB1/Hsp25 and HspB5/αB-crystallin after transient middle cerebral artery occlusion in rats.Cell stress & chaperones · 2017Article
- A comparative transcriptomic analysis of astrocytes differentiation from human neural progenitor cells.The European journal of neuroscience · 2016Article
- Crystallins and neuroinflammation: The glial side of the story.Biochimica et biophysica acta · 2016Article
- Reaction of small heat-shock proteins to different kinds of cellular stress in cultured rat hippocampal neurons.Cell stress & chaperones · 2014Article
- Alpha beta-crystallin expression and presentation following infection with murine gammaherpesvirus 68.Autoimmunity · 2013Article
- Beneficial effects of αB-crystallin in spinal cord contusion injury.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Study of αB-crystallin expression in Gerbil BCAO model of transient global cerebral ischemia.Oxidative medicine and cellular longevity · 2012Article
- The protective and therapeutic function of small heat shock proteins in neurological diseases.Frontiers in immunology · 2012Article
- Systemic augmentation of alphaB-crystallin provides therapeutic benefit twelve hours post-stroke onset via immune modulation.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- Differential response of C57BL/6J mouse and DBA/2J mouse to optic nerve crush.BMC neuroscience · 2009Article
- Vascular actions of estrogens: functional implications.Pharmacological reviews · 2008Review
- A new locus for autosomal dominant posterior polar cataract in Moroccan Jews maps to chromosome 14q22-23.Journal of medical genetics · 2006Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
alphaB-crystallin (alpha-BC), a member of the small heat-shock proteins (sHSP), is constitutively expressed in the vertebrate lens and in non-ocular tissues including the central nervous system (CNS). In this study we investigated the expression of alpha-BC in the rat brain after middle cerebral artery occlusion (MCAO). alpha-BC transcript and protein were transiently expressed 4 h after MCAO/reperfusion in the pyramidal neurons in the peri-infarct region of the ischemic hemisphere. Beginning 2 days after MCAO, significant alpha-BC induction appeared in reactive astrocytes in the penumbra, and this induction was sustained for several days. In addition, levels of MAPKAPK-2, one of the alpha-BC upstream kinases, and its phosphorylated form were upregulated gradually and peaked 4 days after ischemia/reperfusion injury. The immunohistochemical study indicated that alpha-BC was co-localized with MAPKAPK-2 and p-MAPKAPK-2. Furthermore, p38beta MAPK, an upstream kinase of MAPKAPK-2, which has been known to be involved in compensatory responses to stress, was also co-localized with alpha-BC in the penumbra. Our results suggest that the p38beta-dependent alpha-BC induction in neurons and astrocytes in the penumbra may play an important role in the postischemic brain.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.