ArticleOncogene2005
Loss of the LIM domain protein Lmo4 in the mammary gland during pregnancy impedes lobuloalveolar development.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 27 citations in OpenAlex.
- ZnT4 (SLC30A4)-null ("lethal milk") mice have defects in mammary gland secretion and hallmarks of precocious involution during lactation.American journal of physiology. Regulatory, integrative and comparative physiology · 2016Article
- The co-factor of LIM domains (CLIM/LDB/NLI) maintains basal mammary epithelial stem cells and promotes breast tumorigenesis.PLoS genetics · 2014Article
- The dynamics of murine mammary stem/progenitor cells.Frontiers in biology · 2014Article
- Phenotypic and functional characterisation of the luminal cell hierarchy of the mammary gland.Breast cancer research : BCR · 2012Article
- Marginal maternal zinc deficiency in lactating mice reduces secretory capacity and alters milk composition.The Journal of nutrition · 2012Article
- Proliferation of Hepatic Oval Cells via Cyclooxygenase-2 and Extracellular Matrix Protein Signaling during Liver Regeneration Following 2-AAF/Partial Hepatectomy in Rats.Gut and liver · 2011Article
- Zinc in specialized secretory tissues: roles in the pancreas, prostate, and mammary gland.Advances in nutrition (Bethesda, Md.) · 2011Review
- Article
- Repression of Lim only protein 4-activated transcription inhibits proliferation and induces apoptosis of normal mammary epithelial cells and breast cancer cells.Clinical & experimental metastasis · 2010Article
- LMO4 is an essential mediator of ErbB2/HER2/Neu-induced breast cancer cell cycle progression.Oncogene · 2009Article
- Deaf-1 regulates epithelial cell proliferation and side-branching in the mammary gland.BMC developmental biology · 2008Article
- Article
- A zebrafish LMO4 ortholog limits the size of the forebrain and eyes through negative regulation of six3b and rx3.Developmental biology · 2007Article
- c-myc as a mediator of accelerated apoptosis and involution in mammary glands lacking Socs3.The EMBO journal · 2006Article
- Alveolar and lactogenic differentiation.Journal of mammary gland biology and neoplasia · 2006Review
- LMO4 can interact with Smad proteins and modulate transforming growth factor-beta signaling in epithelial cells.Oncogene · 2006Article
- SSeCKS/Gravin/AKAP12 attenuates expression of proliferative and angiogenic genes during suppression of v-Src-induced oncogenesis.BMC cancer · 2006Article
Corrections and comments
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Authors and funding
8 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
LMO4, a member of the LIM-only family of zinc-finger proteins, is overexpressed in a significant proportion of breast carcinomas and acts as a negative regulator of mammary epithelial differentiation. To delineate cell types within the developing mouse mammary gland that express Lmo4, we analysed different stages of mammopoiesis by immunohistochemistry. Lmo4 was found to be highly expressed in the proliferating cap cells of the terminal end bud and in the ductal and alveolar luminal cells of the mature mammary gland but was negligible or low in myoepithelial cells. To assess the physiological role of Lmo4 in the mammary gland, we generated conditionally targeted mice lacking Lmo4 in the mammary epithelium during pregnancy. Acute loss of Lmo4 in late pregnancy impaired lobuloalveolar development, accompanied by a two-fold reduction in the percentage of BrdU-positive cells. In contrast, germline loss of Lmo4 did not alter lobuloalveolar development arising from transplanted mammary anlagen, implying the existence of a compensatory mechanism in these knockout mice. Thus, the use of a conditional targeting strategy has revealed that Lmo4 is required for proper development of the mammary gland during pregnancy and indicated that Lmo4 acts as a positive regulator of alveolar epithelial proliferation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.