ArticleOncogene2005
Inhibitory effect of c-Myc on p53-induced apoptosis in leukemia cells. Microarray analysis reveals defective induction of p53 target genes and upregulation of chaperone genes.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 41 citations in OpenAlex.
- Selenium and vitamin E: cell type- and intervention-specific tissue effects in prostate cancer.Journal of the National Cancer Institute · 2009Trial
- Immortalization of Mesenchymal Stem Cells for Application in Regenerative Medicine and Their Potential Risks of Tumorigenesis.International journal of molecular sciences · 2024Review
- RNA-Binding Proteins in Acute Leukemias.International journal of molecular sciences · 2020Review
- Advantage ofOncotarget · 2018Article
- A highly sensitive trap vector system for isolating reporter cells and identification of responsive genes.Biology methods & protocols · 2018Article
- The dosage of Patz1 modulates reprogramming process.Scientific reports · 2014Article
- MYC and the art of microRNA maintenance.Cold Spring Harbor perspectives in medicine · 2014Review
- miR-375 activates p21 and suppresses telomerase activity by coordinately regulating HPV E6/E7, E6AP, CIP2A, and 14-3-3ζ.Molecular cancer · 2014Article
- Systems analysis of the prostate tumor suppressor NKX3.1 supports roles in DNA repair and luminal cell differentiation.F1000Research · 2014Article
- Diminished origin-licensing capacity specifically sensitizes tumor cells to replication stress.Molecular cancer research : MCR · 2013Article
- The myc road to hearing restoration.Cells · 2012Article
- The human papillomavirus type 16 E7 oncoprotein targets Myc-interacting zinc-finger protein-1.Virology · 2012Article
- Expression of a mutant HSP110 sensitizes colorectal cancer cells to chemotherapy and improves disease prognosis.Nature medicine · 2011Article
- c-Myc influences olaquindox-induced apoptosis in human hepatoma G2 cells.Molecular and cellular biochemistry · 2011Article
- FAK deletion promotes p53-mediated induction of p21, DNA-damage responses and radio-resistance in advanced squamous cancer cells.PloS one · 2011Article
- Determination of genes and microRNAs involved in the resistance to fludarabine in vivo in chronic lymphocytic leukemia.Molecular cancer · 2010Article
- Microarray study of mechanism of trichostatin a inducing apoptosis of Molt-4 cells.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2009Article
- Knockdown of TFIIS by RNA silencing inhibits cancer cell proliferation and induces apoptosis.BMC cancer · 2008Article
- RNA interference of LRRK2-microarray expression analysis of a Parkinson's disease key player.Neurogenetics · 2008Article
- Altered adenosine-to-inosine RNA editing in human cancer.Genome research · 2007Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have previously demonstrated that c-Myc impairs p53-mediated apoptosis in K562 human leukemia cells, which lack ARF. To investigate the mechanisms by which c-Myc protects from p53-mediated apoptosis, we used K562 cells that conditionally express c-Myc and harbor a temperature-sensitive allele of p53. Gene expression profiles of cells expressing wild-type conformation p53 in the presence of either uninduced or induced c-Myc were analysed by cDNA microarrays. The results show that multiple p53 target genes are downregulated when c-Myc is present, including p21WAF1, MDM2, PERP, NOXA, GADD45, DDB2, PIR121 and p53R2. Also, a number of genes that are upregulated by c-Myc in cells expressing wild-type conformation p53 encode chaperones related to cell death protection as HSP105, HSP90 and HSP27. Both downregulation of p53 target genes and upregulation of chaperones could explain the inhibition of apoptosis observed in K562 cells with ectopic c-Myc. Myc-mediated impairment of p53 transactivation was not restricted to K562 cells, but it was reproduced in a panel of human cancer cell lines derived from different tissues. Our data suggest that elevated levels of Myc counteract p53 activity in human tumor cells that lack ARF. This mechanism could contribute to explain the c-Myc deregulation frequently found in cancer.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.