ArticleOncogene2005
A single acute exposure to a chemotherapeutic agent induces hyper-recombination in distantly descendant cells and in their neighbors.
Article in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Lactic Acidosis Interferes With Toxicity of Perifosine to Colorectal Cancer Spheroids: Multimodal Imaging Analysis.Frontiers in oncology · 2020Article
- Inflammation-induced DNA damage, mutations and cancer.DNA repair · 2019Review
- Adaptive responses to low doses of radiation or chemicals: their cellular and molecular mechanisms.Cellular and molecular life sciences : CMLS · 2019Review
- Oxidative DNA damage caused by inflammation may link to stress-induced non-targeted effects.Cancer letters · 2015Review
- High dose bystander effects in spatially fractionated radiation therapy.Cancer letters · 2015Review
- Bystander effects and radiotherapy.Reports of practical oncology and radiotherapy : journal of Greatpoland Cancer Center in Poznan and Polish Society of Radiation Oncology · 2015Review
- Spatially fractionated radiation induces cytotoxicity and changes in gene expression in bystander and radiation adjacent murine carcinoma cells.Radiation research · 2012Article
- Role of Reactive Oxygen Species and Nitric Oxide in Mediating Chemotherapeutic Drug Induced Bystander Response in Human Cancer Cells Exposed In-Vitro.World journal of oncology · 2012Article
- Article
- Mitochondrial mutagenesis induced by tumor-specific radiation bystander effects.Journal of molecular medicine (Berlin, Germany) · 2010Article
- Mitomycin C induces bystander killing in homogeneous and heterogeneous hepatoma cellular models.Molecular cancer · 2009Article
- Transgenic Plants as Sensors of Environmental Pollution Genotoxicity.Sensors (Basel, Switzerland) · 2008Review
- Irradiation induces DNA damage and modulates epigenetic effectors in distant bystander tissue in vivo.Oncogene · 2006Article
- Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Homologous recombination can induce tumorigenic sequence rearrangements. Here, we show that persistent hyper-recombination can be induced following exposure to a bifunctional alkylating agent, mitomycin C (MMC), and that the progeny of exposed cells induce a hyper-recombination phenotype in unexposed neighboring cells. Residual damage cannot be the cause of delayed recombination events, since recombination is observed after drug and template damage are diluted over a million-fold. Furthermore, not only do progeny of MMC-exposed cells induce recombination in unexposed cells (bystanders), but these bystanders can in turn induce recombination in their unexposed neighbors. Thus, a signal to induce homologous recombination can be passed from cell to cell. Although the underlying molecular mechanism is not yet known, these studies reveal that cells suffer consequences of damage long after exposure, and that can signal unexposed neighboring cells to respond similarly. Thus, a single acute exposure to a chemotherapeutic agent can cause long-term changes in genomic stability. If the results of these studies of mouse embryonic stem (ES) cells are generally applicable to many cell types, these results suggest that a relatively small number of cells could potentially induce a tissue-wide increase in the risk of de novo homologous recombination events.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.