ArticleThe American journal of pathology2005
A prostacyclin analog prevents radiocontrast nephropathy via phosphorylation of cyclic AMP response element binding protein.
Article in The American journal of pathology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 45 citations in OpenAlex.
- Iloprost for prevention of contrast-mediated nephropathy in high-risk patients undergoing a coronary procedure. Results of a randomized pilot study.European journal of clinical pharmacology · 2006Trial
- Magnetic vagus nerve stimulation ameliorates contrast-induced acute kidney injury by circulating plasma exosomal miR-365-3p.Journal of nanobiotechnology · 2024Article
- Circulating Exosomal miR-1-3p from Rats with Myocardial Infarction Plays a Protective Effect on Contrast-Induced Nephropathy via Targeting ATG13 and activating the AKT Signaling Pathway.International journal of biological sciences · 2021Article
- PGIInternational journal of molecular sciences · 2020Article
- Molecular mechanisms of renal cellular nephrotoxicity due to radiocontrast media.BioMed research international · 2014Review
- Beraprost sodium attenuates cigarette smoke extract-induced apoptosis in vascular endothelial cells.Molecular biology reports · 2012Article
- Cyclic AMP is both a pro-apoptotic and anti-apoptotic second messenger.Acta physiologica (Oxford, England) · 2012Review
- PGI synthase overexpression protects against bleomycin-induced mortality and is associated with increased Nqo 1 expression.American journal of physiology. Lung cellular and molecular physiology · 2011Article
- Serofendic acid protects from iodinated contrast medium and high glucose probably against superoxide production in LLC-PK1 cells.Clinical and experimental nephrology · 2009Article
- Gentamicin causes apoptosis at low concentrations in renal LLC-PK1 cells subjected to electroporation.Antimicrobial agents and chemotherapy · 2006Article
- Prostaglandin I2 IP Receptor Agonist, Beraprost, Prevents Transient Global Cerebral Ischemia Induced Hippocampal CA1 Injury in Aging Mice.Journal of neurological disordersArticle
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We reported previously that radiocontrast medium induces caspase-dependent apoptosis and that cAMP analogs inhibit cell injury in cultured renal tubular cells. In the present study, cellular mechanisms underlying the protective effects of cAMP were determined. Ioversol, a radiocontrast medium, caused cell injury accompanied by decreases in Bcl-2, increases in Bax, and caspase activation in LLC-PK1 cells. Both cell injury and cellular events induced by ioversol were inhibited by dibutyryl cAMP and the prostacyclin analog beraprost. Dibutyryl cAMP increased phosphorylation of Akt and CREB, both of which were reversed by H89, wortmannin and the Akt inhibitor SH-6. The protective effect of dibutyryl cAMP was also reversed by these kinase inhibitors. In dominant-negative CREB-transfected cells, dibutyryl cAMP no longer prevented cell injury or inhibited changes in mRNA expression of Bcl-2 and Bax. In mice with unilateral renal occlusion, ioversol increased urinary excretion of N-acetyl-beta-d-glucosaminidase with concomitant decreases in Bcl-2 mRNA, increases in Bax mRNA, activation of caspase-3, and induction of apoptosis in tubular and interstitial cells. Beraprost completely reversed these in vivo effects of ioversol. These findings suggest that elevation of endogenous cAMP effectively prevents radiocontrast nephropathy through activation of A kinase/PI 3-kinase/Akt followed by CREB phosphorylation and enhanced expression of Bcl-2.
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