ArticleBMC genomics2005
Investigating hookworm genomes by comparative analysis of two Ancylostoma species.
Article in BMC genomics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Article
- Of dogs and hookworms: man's best friend and his parasites as a model for translational biomedical research.Parasites & vectors · 2018Review
- The genomic basis of nematode parasitism.Briefings in functional genomics · 2018Review
- Secreted proteomes of different developmental stages of the gastrointestinal nematode Nippostrongylus brasiliensis.Molecular & cellular proteomics : MCP · 2014Article
- Article
- Proteomic analysis of secretory products from the model gastrointestinal nematode Heligmosomoides polygyrus reveals dominance of venom allergen-like (VAL) proteins.Journal of proteomics · 2011Article
- Ancylostoma ceylanicum excretory-secretory protein 2 adopts a netrin-like fold and defines a novel family of nematode proteins.Journal of molecular biology · 2011Article
- Screening the Schistosoma mansoni transcriptome for genes differentially expressed in the schistosomulum stage in search for vaccine candidates.Parasitology research · 2011Article
- Article
- Characterizing Ancylostoma caninum transcriptome and exploring nematode parasitic adaptation.BMC genomics · 2010Article
- Massively parallel sequencing and analysis of the Necator americanus transcriptome.PLoS neglected tropical diseases · 2010Article
- Helminth genomics: The implications for human health.PLoS neglected tropical diseases · 2009Review
- The transcriptomes of the cattle parasitic nematode Ostertagia ostartagi.Veterinary parasitology · 2009Article
- The hookworm tissue inhibitor of metalloproteases (Ac-TMP-1) modifies dendritic cell function and induces generation of CD4 and CD8 suppressor T cells.PLoS neglected tropical diseases · 2009Article
- Molecular cloning and DNA binding characterization of DAF-16 orthologs from Ancylostoma hookworms.International journal for parasitology · 2009Article
- Article
- The canine hookworm genome: analysis and classification of Ancylostoma caninum survey sequences.Molecular and biochemical parasitology · 2008Article
- Transcriptional changes in the hookworm, Ancylostoma caninum, during the transition from a free-living to a parasitic larva.PLoS neglected tropical diseases · 2008Article
- Identification and characterization of lineage-specific genes within the Poaceae.Plant physiology · 2007Article
- The bandit, a new DNA transposon from a hookworm-possible horizontal genetic transfer between host and parasite.PLoS neglected tropical diseases · 2007Article
Corrections and comments
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Authors and funding
13 authors.
Funding
Abstract
backgroundHookworms, infecting over one billion people, are the mostly closely related major human parasites to the model nematode Caenorhabditis elegans. Applying genomics techniques to these species, we analyzed 3,840 and 3,149 genes from Ancylostoma caninum and A. ceylanicum.
resultsTranscripts originated from libraries representing infective L3 larva, stimulated L3, arrested L3, and adults. Most genes are represented in single stages including abundant transcripts like hsp-20 in infective L3 and vit-3 in adults. Over 80% of the genes have homologs in C. elegans, and nearly 30% of these were with observable RNA interference phenotypes. Homologies were identified to nematode-specific and clade V specific gene families. To study the evolution of hookworm genes, 574 A. caninum/A. ceylanicum orthologs were identified, all of which were found to be under purifying selection with distribution ratios of nonsynonymous to synonymous amino acid substitutions similar to that reported for C. elegans/C. briggsae orthologs. The phylogenetic distance between A. caninum and A. ceylanicum is almost identical to that for C. elegans/C. briggsae.
conclusionThe genes discovered should substantially accelerate research toward better understanding of the parasites' basic biology as well as new therapies including vaccines and novel anthelmintics.
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