ArticleThe Journal of experimental medicine2005
Differential requirements for the chemokine receptor CCR7 in T cell activation during Listeria monocytogenes infection.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
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Who cites it
31 citing papers in PubMed, 65 citations in OpenAlex.
- Dysregulated NAMPT signaling underlines the immune-suppressive microenvironment in venous leg ulcers.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- γδ T cell-mediated activation of cDC1 orchestrates CD4Frontiers in immunology · 2024Article
- Splenic stromal niches in homeostasis and immunity.Nature reviews. Immunology · 2023Review
- Single cell transcriptomic landscape of diabetic foot ulcers.Nature communications · 2022Article
- Single-Cell Landscape of Mouse Islet Allograft and Syngeneic Graft.Frontiers in immunology · 2022Article
- Of Lymph Nodes and CLL Cells: Deciphering the Role of CCR7 in the Pathogenesis of CLL and Understanding Its Potential as Therapeutic Target.Frontiers in immunology · 2021Review
- CCR7 in Blood Cancers - Review of Its Pathophysiological Roles and the Potential as a Therapeutic Target.Frontiers in oncology · 2021Review
- CD39 is upregulated during activation of mouse and human T cells and attenuates the immune response to Listeria monocytogenes.PloS one · 2018Article
- CCR7 Deficiency Allows Accelerated Clearance ofJournal of immunology (Baltimore, Md. : 1950) · 2017Article
- Chemokine Receptor Ccr7 Restricts Fatal West Nile Virus Encephalitis.Journal of virology · 2017Article
- Absence of system xJournal of neuroinflammation · 2017Article
- Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation.The EMBO journal · 2016Article
- Cutting Edge: The Orphan Nuclear Receptor Nr4a1 Regulates CD8+ T Cell Expansion and Effector Function through Direct Repression of Irf4.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- In vivo approaches reveal a key role for DCs in CD4+ T cell activation and parasite clearance during the acute phase of experimental blood-stage malaria.PLoS pathogens · 2015Article
- Notch1-induced T cell leukemia can be potentiated by microenvironmental cues in the spleen.Journal of hematology & oncology · 2014Article
- Article
- The transcription factor Interferon Regulatory Factor 4 is required for the generation of protective effector CD8+ T cells.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Convolution of chemoattractant secretion rate, source density, and receptor desensitization direct diverse migration patterns in leukocytes.Integrative biology : quantitative biosciences from nano to macro · 2013Article
- The absence of CCR7 results in dysregulated monocyte migration and immunosuppression facilitating chronic cutaneous leishmaniasis.PloS one · 2013Article
- Role of C-C chemokine receptor type 7 and its ligands during neuroinflammation.Journal of neuroinflammation · 2012Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Effective priming of T cell responses depends on cognate interactions between naive T cells and professional antigen-presenting cells (APCs). This contact is the result of highly coordinated migration processes, in which the chemokine receptor CCR7 and its ligands, CCL19 and CCL21, play a central role. We used the murine Listeria monocytogenes infection model to characterize the role of the CCR7/CCR7 ligand system in the generation of T cell responses during bacterial infection. We demonstrate that efficient priming of naive major histocompatibility complex (MHC) class Ia-restricted CD8+ T cells requires CCR7. In contrast, MHC class Ib-restricted CD8+ T cells and MHC class II-restricted CD4+ T cells seem to be less dependent on CCR7; memory T cell responses are independent of CCR7. Infection experiments with bone marrow chimeras or mice reconstituted with purified T cell populations indicate that CCR7 has to be expressed on CD8+ T cells and professional APCs to promote efficient MHC class Ia-restricted T cell priming. Thus, different T cell subtypes and maturation stages have discrete requirements for CCR7.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.