ArticleNucleic acids research2005
The repressor DREAM acts as a transcriptional activator on Vitamin D and retinoic acid response elements.
Article in Nucleic acids research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 39 citations in OpenAlex.
- KCells · 2023Review
- Emerging Role of DREAM in Healthy Brain and Neurological Diseases.International journal of molecular sciences · 2023Review
- CaFrontiers in molecular neuroscience · 2018Review
- Inhibition of the Neuronal Calcium Sensor DREAM Modulates Presenilin-2 Endoproteolysis.Frontiers in molecular neuroscience · 2018Article
- Kv channel-interacting proteins as neuronal and non-neuronal calcium sensors.Channels (Austin, Tex.) · 2018Review
- Hydrogen-Deuterium Exchange Mass Spectrometry Reveals Calcium Binding Properties and Allosteric Regulation of Downstream Regulatory Element Antagonist Modulator (DREAM).Biochemistry · 2017Article
- Structure and Calcium Binding Properties of a Neuronal Calcium-Myristoyl Switch Protein, Visinin-Like Protein 3.PloS one · 2016Article
- Vitamin D receptor and RXR in the post-genomic era.Journal of cellular physiology · 2015Review
- Vitamin D and the RNA transcriptome: more than mRNA regulation.Frontiers in physiology · 2014Review
- Protein-Protein Interactions: Gene Acronym Redundancies and Current Limitations Precluding Automated Data Integration.Proteomes · 2013Article
- Understanding the physiological roles of the neuronal calcium sensor proteins.Molecular brain · 2012Review
- The calcium: an early signal that initiates the formation of the nervous system during embryogenesis.Frontiers in molecular neuroscience · 2012Article
- Reduced Mid1 Expression and Delayed Neuromotor Development in daDREAM Transgenic Mice.Frontiers in molecular neuroscience · 2012Article
- Transcriptional regulation by small RNAs at sequences downstream from 3' gene termini.Nature chemical biology · 2010Article
- PACAP signaling to DREAM: a cAMP-dependent pathway that regulates cortical astrogliogenesis.Molecular neurobiology · 2009Review
- DREAM mediates cAMP-dependent, Ca2+-induced stimulation of GFAP gene expression and regulates cortical astrogliogenesis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2008Article
- Distribution of downstream regulatory element antagonist modulator (DREAM) in rat spinal cord and upregulation of its expression during inflammatory pain.Neurochemical research · 2007Article
- Downstream regulatory element antagonist modulator regulates Ca2+ homeostasis and viability in cerebellar neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
DREAM (downstream regulatory element antagonist modulator) is a transcriptional repressor, which binds DREs (downstream response elements) in a Ca2+-regulated manner. The DREs consist of core GTCA motifs, very similar to binding motifs for non-steroid nuclear receptors. In this work, we find that DREAM stimulates basal and ligand-dependent activation of promoters containing vitamin D and retinoic acid response elements (VDREs and RAREs), consisting of direct repeats of the sequence AGT/GTCA spaced by 3 or 5 nt, respectively. Stimulation occurs when the element is located upstream, but not downstream, the transcription initiation site. Activation requires both Ca2+ binding to the EF-hands and the leucine-charged domains (LCDs), analogous to those responsible for the interaction of the nuclear receptors with coregulators. Further more, DREAM can bind both 'in vitro' and in chromatin immunoprecipitation assays to these elements. Importantly, 'in vivo' binding is only observed in vitamin D- or RA-treated cells. These results show that DREAM can function as an activator of transcription on certain promoters and demonstrate a novel role for DREAM acting as a potential modulator of genes containing binding sites for nuclear receptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.