ArticleBiophysical journal2005
Electrochemical and PM-IRRAS studies of the effect of cholesterol on the structure of a DMPC bilayer supported at an Au (111) electrode surface, part 1: properties of the acyl chains.
Article in Biophysical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Article
- Cellular absorption of small molecules: free energy landscapes of melatonin binding at phospholipid membranes.Scientific reports · 2020Article
- Characterization of the interactions between fluoroquinolone antibiotics and lipids: a multitechnique approach.Biophysical journal · 2008Article
- Biophysical effects of electric fields on membrane water interfaces: a mini review.European biophysics journal : EBJ · 2007Review
- Tethered bilayer lipid membranes studied by simultaneous attenuated total reflectance infrared spectroscopy and electrochemical impedance spectroscopy.The journal of physical chemistry. B · 2007Article
- Tilt angle of lipid acyl chains in unilamellar vesicles determined by ellipsometric light scattering.The European physical journal. E, Soft matter · 2007Article
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Authors and funding
3 authors.
Funding
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Abstract
Charge density measurements and polarization modulation infrared reflection absorption spectroscopy were employed to investigate the spreading of small unilamellar vesicles of a dimyristoylphosphatidylcholine (DMPC)/cholesterol (7:3 molar ratio) mixture onto an Au (111) electrode surface. The electrochemical experiments demonstrated that vesicles fuse and spread onto the Au (111) electrode surface, forming a bilayer, at rational potentials -0.4 V < (E - Epzc) < 0.4 V or field strength <6 x 10(7) V m(-1). Polarization modulation infrared reflection absorption spectroscopy experiments provided information concerning the conformation and orientation of the acyl chains of DMPC molecules. Deuterated DMPC was used to subtract the contribution of C-H stretching bands of cholesterol and of the polar head region of DMPC from spectra in the C-H stretching region. The absorption spectra of the C-H stretch bands in the acyl chains were determined in this way. The properties of the DMPC/cholesterol bilayer have been compared with the properties of a pure DMPC bilayer. The presence of 30% cholesterol gives a thicker and more fluid bilayer characterized by a lower capacity and lower tilt angle of the acyl chains.
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