ArticleBritish journal of cancer2005
Identification of novel growth factor-responsive genes in neuroendocrine gastrointestinal tumour cells.
Article in British journal of cancer, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- The differentially expressed gene signatures of the Cullin 3-RING ubiquitin ligases in neuroendocrine cancer.Biochemical and biophysical research communications · 2022Article
- Identification of HOXA1 as a Novel Biomarker in Prognosis of Head and Neck Squamous Cell Carcinoma.Frontiers in molecular biosciences · 2020Article
- Lanreotide Induces Cytokine Modulation in Intestinal Neuroendocrine Tumors and Overcomes Resistance to Everolimus.Frontiers in oncology · 2020Article
- SRC family kinase FYN promotes the neuroendocrine phenotype and visceral metastasis in advanced prostate cancer.Oncotarget · 2015Article
- Article
- Loss-of-function mutations in RAB18 cause Warburg micro syndrome.American journal of human genetics · 2011Article
- Rab proteins and the secretory pathway: the case of rab18 in neuroendocrine cells.Frontiers in endocrinology · 2011Article
- Changes in the expression of pituitary adenylate cyclase-activating polypeptide in the human placenta during pregnancy and its effects on the survival of JAR choriocarcinoma cells.Journal of molecular neuroscience : MN · 2010Article
- IL-2 -330 T/G SNP and serum values-potential new tumor markers in neuroendocrine tumors of the gastrointestinal tract and pancreas (GEP-NETs).Journal of molecular medicine (Berlin, Germany) · 2010Article
- PACAP induces signaling and stimulation of 5-hydroxytryptamine release and growth in neuroendocrine tumor cells.Journal of molecular neuroscience : MN · 2009Article
- Identification of novel neuroendocrine-specific tumour genes.British journal of cancer · 2008Article
- Optimization of cDNA microarrays procedures using criteria that do not rely on external standards.BMC genomics · 2007Article
- Overexpression of wild-type PKD2 leads to increased proliferation and invasion of BON endocrine cells.Biochemical and biophysical research communications · 2006Article
- Genes involved in neuroendocrine tumor biology.Pituitary · 2006Review
Corrections and comments
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Targeting growth-regulatory pathways is a promising approach in cancer treatment. A prerequisite to the development of such therapies is characterisation of tumour growth regulation in the particular tumour cell type of interest. In order to gain insight into molecular mechanisms underlying proliferative responses in neuroendocrine (NE) gastrointestinal (GI) tumours, we investigated gene expression in human carcinoid BON cells after exposure to gastrin, hepatocyte growth factor (HGF), pituitary adenylate cyclase-activating polypeptide or epidermal growth factor. We particularly focused on gastrin- and HGF-induced gene expression, and identified 95 gastrin- and 101 HGF-responsive genes. The majority of these genes are known mediators of processes central in tumour biology, and a number of them have been associated with poor prognosis and metastasis in cancer patients. Furthermore, we identified 12 genes that were regulated by all four factors, indicating that they may be universally regulated during NE GI tumour cell proliferation. Our findings provide useful hypotheses for further studies aimed to search for new therapeutic targets as well as tumour markers in NE GI tumours.
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