Evidence map›Paper›PMID 15846257›Full record

ArticleAmerican heart journal2005

Characteristics and outcomes of patients hospitalized for heart failure in the United States: rationale, design, and preliminary observations from the first 100,000 cases in the Acute Decompensated Heart Failure National Registry (ADHERE).

Kirkwood F Adams, Gregg C Fonarow, Charles L Emerman, Thierry H LeJemtel, Maria Rosa Costanzo, William T Abraham, Robert L Berkowitz, Marie Galvao, Darlene P Horton, ADHERE Scientific Advisory Committee and Investigators

9 registry-linked trialsAbstract read
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In one paragraph

Article in American heart journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 9 registered trials, which are not on this map. Cited by 728 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
728citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04298229 phase3completedstarted 2020, after this paper: background citation

A Randomized, Open-label Study of Dapagliflozin in Patients With or Without Type 2 Diabetes Admitted With Acute Heart Failure

Ran2020Enrolled240Registered outcomes3Posted comparisons0ConditionsDiabetes Mellitus, Type 2, Heart FailureArmsDapagliflozin 10 mg, Protocolized Diuretic Therapy
Open the trial in the graph
NCT00530426 completednot on this map

ADHERE Core II - Acute Decompensated HEart Failure REgistry

TypeobservationalSponsorScios, Inc.Ran2001 to 2005Enrolled150,000ConditionsHeart Failure, Congestive
NCT01474200 naterminatednot on this mapstarted 2012, after this paper: background citation

Aquapheresis Versus Intravenous Diuretics and Hospitalizations for Heart Failure (AVOID-HF)

TypeinterventionalSponsorNuwellis, Inc.Ran2012 to 2014Enrolled224ConditionsHeart Failure, Cardiac Failure, Acute Decompensated Heart Failure (ADHF)ArmsIsolated veno-venous ultrafiltration (AQ), IV Loop Diuretics (LD)
NCT01956539 completednot on this mapstarted 2014, after this paper: background citation

FREnch Survey on Heart Failure

Typeobservational_patient_registrySponsorFrench Cardiology SocietyRan2014 to 2022Enrolled2,719ConditionsHeart Failure, Observational Study
NCT02353481 unknown statusnot on this mapstarted 2012, after this paper: background citation

1 Year Post Discharge Prognostic Model From the National Heart Failure Audit (NHFA)

TypeobservationalSponsorUniversity College, LondonRan2012 to 2015Enrolled63,320ConditionsHeart FailureArmsHeart Failure Management
NCT02429388 phase4withdrawnnot on this mapstarted 2014, after this paper: background citation

High-Dose Aldactone for Treatment of Diuretic Resistant Heart Failure

TypeinterventionalSponsorThe University of Texas Health Science Center at San AntonioRan2014 to 2015Enrolled0ConditionsHeart FailureArmsSpironolactone
NCT04572867 nawithdrawnnot on this mapstarted 2021, after this paper: background citation

Efficacy of Aquapheresis in Patients Treated as Outpatients With Decompensated Heart Failure at a Veterans Hospital

TypeinterventionalSponsorRamona Gelzer BellRan2021 to 2021Enrolled0ConditionsHeart Failure, Congestive Heart Failure, Decompensated Heart FailureArmsAquapheresis, IV Diuretics
NCT05204238 unknown statusnot on this mapstarted 2020, after this paper: background citation

Follow Up of acuTe Heart failUre: a pRospective Echocardiographic and Clinical Study (FUTURE)

TypeobservationalSponsorUniversity of SienaRan2020 to 2022Enrolled998ConditionsHeart Failure, Heart Failure With Preserved Ejection Fraction, Heart Failure With Mid Range Ejection Fraction, Heart Failure With Reduced Ejection FractionArmsTransthoracic Echocardiography
NCT05295641 completednot on this mapstarted 2022, after this paper: background citation

American Registry of Ambulatory or Acutely Decompensated Heart Failure

Typeobservational_patient_registrySponsorFundacion Clinica Valle del LiliRan2022 to 2025Enrolled6,732ConditionsHeart Failure, Acute Heart Failure (AHF), Chronic Heart Failure
3 · Its place in the literature

Who cites it

728 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
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  5. Trial
  6. Trial
  7. Bioimpedance utility in heart failure.Heart failure reviews · 2026
    Review
  8. An integrated overview of acute heart failure: a narrative review of pathophysiological mechanisms and contributing factors.The Egyptian heart journal : (EHJ) : official bulletin of the Egyptian Society of Cardiology · 2026
    Review
  9. Article
  10. Review
  11. Article
  12. Diuretics in Cardiovascular Disease: For How Long and at What Dose?Journal of cardiovascular development and disease · 2026
    Review
  13. A platelet-monocyte pyroptotic axis mediates uremic cardiomyopathy: critical role of PF4 and hematopoietic caspase-1.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2026
    Article
  14. Article
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  18. Review
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  20. Review

668 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kirkwood F AdamsDivision of Cardiology, University of North Carolina, Chapel Hill, NC, USA. kfa@med.unc.edu
Gregg C Fonarow
Charles L Emerman
Thierry H LeJemtel
Maria Rosa Costanzo
William T Abraham
Robert L Berkowitz
Marie Galvao
Darlene P Horton
ADHERE Scientific Advisory Committee and Investigators

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe ADHERE is designed to study characteristics, management, and outcomes in a broad sample of patients hospitalized with acute decompensated heart failure. Heart failure is a leading cause of hospitalization for adults older than 65 years in the United States. Most available data on these patients are limited by patient selection criteria and study design of clinical trials and single-center studies.

methodsParticipating hospitals identify patients with a primary or secondary discharge diagnosis of heart failure. Medical history, management, treatments, and health outcomes data are collected through review of medical records and entered into a database via secure web browser technology.

resultsAs of January 2004, data on 107 362 patients have been received from 282 participating hospitals. Of enrollees with available analyzable data (N = 105 388 from 274 hospitals), the mean age was 72.4 (+/-14.0), and 52% were women. The most common comorbid conditions were hypertension (73%), coronary artery disease (57%), and diabetes (44%). Evidence of mild or no impairment of systolic function was found in 46% of patients. Inhospital mortality was 4.0% and the median hospital length of stay was 4.3 days.

conclusionsThe ADHERE demonstrates both the feasibility and significant implications of gathering representative data on large numbers of patients hospitalized with heart failure. Initial data provided important insights into the clinical characteristics and patterns of care of these patients. Ongoing registry work will provide the framework for improved treatment strategies for patients hospitalized with decompensated heart failure.

Indexed as

RegistriesAgedComorbidityConfidentialityDatabases, FactualFemaleHeart FailureHospitalizationHospital MortalityHumansLength of StayMaleMiddle AgedQuality of Health CareTreatment OutcomeUnited States

Identifiers

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

and 3 more above

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.