ArticleProceedings of the National Academy of Sciences of the United States of America2005
Temporal profile of replication of human chromosomes.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
62 citing papers in PubMed.
- Genomic methods for measuring DNA replication dynamics.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2020Review
- Novel candidate biomarkers of origin recognition complex 1, 5 and 6 for survival surveillance in patients with hepatocellular carcinoma.Journal of Cancer · 2020Article
- Next-Generation Sequencing Enables Spatiotemporal Resolution of Human Centromere Replication Timing.Genes · 2019Article
- Review
- Identification of the ORC Complex Subunits That Can Interact with the ENY2 Protein of Drosophila melanogaster.Doklady. Biochemistry and biophysics · 2018Article
- DNA replication origins-where do we begin?Genes & development · 2016Review
- DNA replication and transcription programs respond to the same chromatin cues.Genome research · 2014Article
- A new light on DNA replication from the inactive X chromosome.BioEssays : news and reviews in molecular, cellular and developmental biology · 2014Review
- Temporal separation of replication and transcription during S-phase progression.Cell cycle (Georgetown, Tex.) · 2014Article
- Bubble-seq analysis of the human genome reveals distinct chromatin-mediated mechanisms for regulating early- and late-firing origins.Genome research · 2013Article
- Alterations in replication timing of cancer-related genes in malignant human breast cancer cells.Journal of cellular biochemistry · 2013Article
- DNA replication timing and higher-order nuclear organization determine single-nucleotide substitution patterns in cancer genomes.Nature communications · 2013Article
- Multiscale analysis of genome-wide replication timing profiles using a wavelet-based signal-processing algorithm.Nature protocols · 2013Article
- Initiation of DNA Replication in the Human Genome.Hereditary genetics : current research · 2012Article
- The effect of the intra-S-phase checkpoint on origins of replication in human cells.Genes & development · 2011Article
- Bubble-chip analysis of human origin distributions demonstrates on a genomic scale significant clustering into zones and significant association with transcription.Genome research · 2011Article
- Developmental control of the DNA replication and transcription programs.Genome research · 2011Article
- Comparative analysis of DNA replication timing reveals conserved large-scale chromosomal architecture.PLoS genetics · 2010Article
- Integrating one-dimensional and three-dimensional maps of genomes.Journal of cell science · 2010Article
- Arabidopsis thaliana chromosome 4 replicates in two phases that correlate with chromatin state.PLoS genetics · 2010Article
2 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Chromosomes in human cancer cells are expected to initiate replication from predictably localized origins, firing reproducibly at discrete times in S phase. Replication products obtained from HeLa cells at different stages of S phase were hybridized to cDNA and genome tiling oligonucleotide microarrays to determine the temporal profile of replication of human chromosomes on a genome-wide scale. About 1,000 genes and chromosomal segments were identified as sites containing efficient origins that fire reproducibly. Early replication was correlated with high gene density. An acute transition of gene density from early to late replicating areas suggests that discrete chromatin states dictate early versus late replication. Surprisingly, at least 60% of the interrogated chromosomal segments replicate equally in all quarters of S phase, suggesting that large stretches of chromosomes are replicated by inefficient, variably located and asynchronous origins and forks, producing a pan-S phase pattern of replication. Thus, at least for aneuploid cancer cells, a typical discrete time of replication in S phase is not seen for large segments of the chromosomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.