ArticleInfection and immunity2005
Maturation of the Legionella pneumophila-containing phagosome into a phagolysosome within gamma interferon-activated macrophages.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 51 citations in OpenAlex.
- Effector-mediated subversion of proteasome activator (PA)28αβ enhances host defense against Legionella pneumophila under inflammatory and oxidative stress conditions.PLoS pathogens · 2023Article
- Atg5-Deficient Mice Infected withMicroorganisms · 2020Article
- Potentiation of Cytokine-Mediated Restriction ofJournal of bacteriology · 2019Article
- Article
- Lysophosphatidylcholine Promotes Phagosome Maturation and Regulates Inflammatory Mediator Production Through the Protein Kinase A-Phosphatidylinositol 3 Kinase-p38 Mitogen-Activated Protein Kinase Signaling Pathway DuringFrontiers in immunology · 2018Article
- Article
- Evolution of Cell-Autonomous Effector Mechanisms in Macrophages versus Non-Immune Cells.Microbiology spectrum · 2016Review
- Type II Secretion Is Necessary for Optimal Association of the Legionella-Containing Vacuole with Macrophage Rab1B but Enhances Intracellular Replication Mainly by Rab1B-Independent Mechanisms.Infection and immunity · 2016Article
- Legionella pneumophila-Derived Outer Membrane Vesicles Promote Bacterial Replication in Macrophages.PLoS pathogens · 2016Article
- Neutrophil and Alveolar Macrophage-Mediated Innate Immune Control of Legionella pneumophila Lung Infection via TNF and ROS.PLoS pathogens · 2016Article
- The Sphingosine-1-Phosphate Lyase (LegS2) Contributes to the Restriction of Legionella pneumophila in Murine Macrophages.PloS one · 2016Article
- Endoplasmic Reticulum Tubule Protein Reticulon 4 Associates with the Legionella pneumophila Vacuole and with Translocated Substrate Ceg9.Infection and immunity · 2015Article
- Identification of an immune-regulated phagosomal Rab cascade in macrophages.Journal of cell science · 2014Article
- The transcriptome of Legionella pneumophila-infected human monocyte-derived macrophages.PloS one · 2014Article
- Revisiting caspase-11 function in host defense.Cell host & microbe · 2013Review
- A bacterial protein promotes the recognition of the Legionella pneumophila vacuole by autophagy.European journal of immunology · 2013Article
- Biofilm-derived Legionella pneumophila evades the innate immune response in macrophages.Frontiers in cellular and infection microbiology · 2013Article
- Nitric oxide-mediated intracellular growth restriction of pathogenic Rhodococcus equi can be prevented by iron.Infection and immunity · 2011Article
- Molecular characterization of the Dot/Icm-translocated AnkH and AnkJ eukaryotic-like effectors of Legionella pneumophila.Infection and immunity · 2010Article
- Replication of Legionella Pneumophila in Human Cells: Why are We Susceptible?Frontiers in microbiology · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
Legionella pneumophila is an intracellular pathogen that modulates the biogenesis of its phagosome to evade endocytic vesicle traffic. The Legionella-containing phagosome (LCP) does not acquire any endocytic markers and is remodeled by the endoplasmic reticulum during early stages. Here we show that intracellular replication of L. pneumophila is inhibited in gamma interferon (IFN-gamma)-activated, bone marrow-derived mouse macrophages and IFN-gamma-activated, human monocyte-derived macrophages in a dose-dependent manner. This inhibition of intracellular replication is associated with the maturation of the LCP into a phagolysosome, as documented by the acquisition of LAMP-2, cathepsin D, and lysosomal tracer Texas Red ovalbumin, and with the failure of the LCP to be remodeled by the rough endoplasmic reticulum. We conclude that IFN-gamma-activated macrophages override the ability of L. pneumophila to evade endocytic fusion and that the LCP is processed through the "default" endosomal-lysosomal degradation pathway.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.