ArticleInfection and immunity2005
Induction of Mycobacterium tuberculosis-specific primary and secondary T-cell responses in interleukin-15-deficient mice.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
18 citing papers in PubMed, 36 citations in OpenAlex.
- Review
- Limited recognition of Mycobacterium tuberculosis-infected macrophages by polyclonal CD4 and CD8 T cells from the lungs of infected mice.Mucosal immunology · 2020Article
- Th1 cytokines, true functional signatures for protective immunity against TB?Cellular & molecular immunology · 2018Review
- Trans-presentation of interleukin-15 by interleukin-15 receptor alpha is dispensable for the pathogenesis of autoimmune type 1 diabetes.Cellular & molecular immunology · 2017Article
- Article
- Current efforts and future prospects in the development of live mycobacteria as vaccines.Expert review of vaccines · 2015Review
- Host defense and recruitment of Foxp3⁺ T regulatory cells to the lungs in chronic Mycobacterium tuberculosis infection requires toll-like receptor 2.PLoS pathogens · 2013Article
- Rapid down-regulation of γc on T cells in early SIV infection correlates with impairment of T-cell function.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2012Article
- Aptamer inhibits Mycobacterium tuberculosis (H37Rv) invasion of macrophage.Molecular biology reports · 2012Article
- The role of interleukin-15 in inflammation and immune responses to infection: implications for its therapeutic use.Microbes and infection · 2012Review
- Impact of toll-like receptor 2 deficiency on immune responses to mycobacterial antigens.Infection and immunity · 2011Article
- Development of a secondary immune response to Mycobacterium tuberculosis is independent of Toll-like receptor 2.Infection and immunity · 2011Article
- Aberrant TGF-beta signaling reduces T regulatory cells in ICAM-1-deficient mice, increasing the inflammatory response to Mycobacterium tuberculosis.Journal of leukocyte biology · 2009Article
- IL-15 links TLR2/1-induced macrophage differentiation to the vitamin D-dependent antimicrobial pathway.Journal of immunology (Baltimore, Md. : 1950) · 2008Article
- Poor correlation between BCG vaccination-induced T cell responses and protection against tuberculosis.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Differential immune regulation of activated T cells between cutaneous and mucosal leishmaniasis as a model for pathogenesis.Parasite immunology · 2007Article
- Coimmunization with IL-15 plasmid enhances the longevity of CD8 T cells induced by DNA encoding hepatitis B virus core antigen.World journal of gastroenterology · 2006Article
- Microarray analysis of the in vitro granulomatous response to Mycobacterium tuberculosis H37Ra.Colombia medica (Cali, Colombia)Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Several studies have provided evidence that interleukin-15 (IL-15) can enhance protective immune responses against Mycobacterium tuberculosis infection. However, the effects of IL-15 deficiency on the functionality of M. tuberculosis-specific CD4 and CD8 T cells are unknown. In this study, we investigated the generation and maintenance of effector and memory T-cell responses following M. tuberculosis infection of IL-15(-/-) mice. IL-15(-/-) mice had slightly higher bacterial numbers during chronic infection, which were accompanied by an increase in gamma interferon (IFN-gamma)-producing CD4 and CD8 T cells. There was no evidence of increased apoptosis or a defect in proliferation of CD8 effector T cells following M. tuberculosis infection. The induction of cytotoxic and IFN-gamma CD8 T-cell responses was normal in the absence of IL-15 signaling. The infiltration of CD4 and CD8 T cells into the lungs of "immune" IL-15(-/-) mice was delayed in response to M. tuberculosis challenge. These findings demonstrate that efficient effector CD4 and CD8 T cells can be developed following M. tuberculosis infection in the absence of IL-15 but that recall T-cell responses may be impaired.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.