ArticleInfection and immunity2005
Use of in vivo-induced antigen technology for identification of Escherichia coli O157:H7 proteins expressed during human infection.
Article in Infection and immunity, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 58 citations in OpenAlex.
- Metabolism of L-arabinose converges with virulence regulation to promote enteric pathogen fitness.Nature communications · 2024Article
- Strain and host-cell dependent role of type-1 fimbriae in the adherence phenotype of super-shed Escherichia coli O157:H7.International journal of medical microbiology : IJMM · 2021Article
- Interplay between enterohaemorrhagicEmerging microbes & infections · 2020Article
- Role of the Nitric Oxide Reductase NorVW in the Survival and Virulence of EnterohaemorrhagicPathogens (Basel, Switzerland) · 2020Article
- Article
- Identification and prevalence of in vivo-induced genes in enterohaemorrhagic Escherichia coli.Virulence · 2019Article
- Article
- Immunoprotective Efficacy of SixFrontiers in microbiology · 2016Article
- Identification of Enterococcus faecalis antigens specifically expressed in vivo.Restorative dentistry & endodontics · 2015Article
- Vaccines for viral and bacterial pathogens causing acute gastroenteritis: Part II: Vaccines for Shigella, Salmonella, enterotoxigenic E. coli (ETEC) enterohemorragic E. coli (EHEC) and Campylobacter jejuni.Human vaccines & immunotherapeutics · 2015Review
- Immunoproteomic analysis to identify Shiga toxin-producing Escherichia coli outer membrane proteins expressed during human infection.Infection and immunity · 2014Article
- Article
- Identification of Salmonella enterica serovar Pullorum antigenic determinants expressed in vivo.Infection and immunity · 2013Article
- Identification and real-time expression analysis of selected Toxoplasma gondii in-vivo induced antigens recognized by IgG and IgM in sera of acute toxoplasmosis patients.BMC infectious diseases · 2013Article
- Proteins other than the locus of enterocyte effacement-encoded proteins contribute to Escherichia coli O157:H7 adherence to bovine rectoanal junction stratified squamous epithelial cells.BMC microbiology · 2012Article
- Identification of in vivo-induced antigens including an RTX family exoprotein required for uropathogenic Escherichia coli virulence.Infection and immunity · 2011Article
- Staphylococcus aureus seroproteomes discriminate ruminant isolates causing mild or severe mastitis.Veterinary research · 2011Article
- Identification of Leishmania proteins preferentially released in infected cells using change mediated antigen technology (CMAT).PLoS neglected tropical diseases · 2010Article
- Use of in vivo-induced antigen technology (IVIAT) for the identification of Streptococcus suis serotype 2 in vivo-induced bacterial protein antigens.BMC microbiology · 2009Article
- Comprehensive identification of Salmonella enterica serovar typhimurium genes required for infection of BALB/c mice.PLoS pathogens · 2009Article
Corrections and comments
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Authors and funding
12 authors at 5 institutions in 1 country.
Funding
Abstract
Using in vivo-induced antigen technology (IVIAT), a modified immunoscreening technique that circumvents the need for animal models, we directly identified immunogenic Escherichia coli O157:H7 (O157) proteins expressed either specifically during human infection but not during growth under standard laboratory conditions or at significantly higher levels in vivo than in vitro. IVIAT identified 223 O157 proteins expressed during human infection, several of which were unique to this study. These in vivo-induced (ivi) proteins, encoded by ivi genes, mapped to the backbone, O islands (OIs), and pO157. Lack of in vitro expression of O157-specific ivi proteins was confirmed by proteomic analysis of a mid-exponential-phase culture of E. coli O157 grown in LB broth. Because ivi proteins are expressed in response to specific cues during infection and might help pathogens adapt to and counter hostile in vivo environments, those identified in this study are potential targets for drug and vaccine development. Also, such proteins may be exploited as markers of O157 infection in stool specimens.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.