ReviewToxicology and applied pharmacology2005
Molecular and ionic mimicry and the transport of toxic metals.
Review in Toxicology and applied pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 198 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
198 citing papers in PubMed, 3 syntheses or guidelines pooled it, 761 citations in OpenAlex.
- Exploring cadmium exposure as a contributor to male infertility: insights from the relationship between environmental pollutants and the male reproductive system.Frontiers in endocrinology · 2026Pooled it
- Heavy metal carcinogenicity: a scoping review of observational & experimental evidence.Frontiers in oncology · 2025Pooled it
- Evaluation of Fetal Exposures to Metals and Metalloids through Meconium Analyses: A Review.International journal of environmental research and public health · 2021Pooled it
- Quantum dot sensors for heavy metal detection: from mechanistic design to field deployment: a review.RSC advances · 2026Review
- Impact of environmental heavy metal exposure on cardiovascular disease mortality.American journal of preventive cardiology · 2026Article
- Methylene blue for treating toxic encephalopathy due to acute nickel poisoning: A case report.World journal of critical care medicine · 2026Article
- The Impact of Cadmium Telluride Quantum Dots on Male Reproductive Health: A Systematic Review of Toxicological Effects and Mechanisms.The world journal of men's health · 2026Review
- Transporter promiscuity and redox-driven metal partitioning in plant responses to chemically analogous metals.Plant cell reports · 2026Review
- Acute toxicity of metals in Rhinella diptycha and Leptodactylus fuscus at different temperatures: a perspective for tropical tadpoles.Ecotoxicology (London, England) · 2026Article
- Article
- Unravelling Mechanisms of Oxinflammation Induced by Heavy Metals.Metabolites · 2026Review
- Distribution of Toxic and Essential Elements in Autopsy Organs of Subjects Living in South-Eastern Poland.International journal of molecular sciences · 2026Article
- Metallomic Analysis of Vitreous Humor of the Human Eye-A Post-Mortem Multielemental Study.International journal of molecular sciences · 2026Article
- Association between multiple urinary metals and visceral obesity: a large cross-sectional study in South China.European journal of medical research · 2026Article
- Airborne metals and malignant pleural effusions: the role of oxidative stress.Frontiers in toxicology · 2026Review
- Artificial Intelligence Decodes Brain Elemental Signatures to Stratify Aging and Neurological Diseases.Research (Washington, D.C.) · 2026Article
- Binding of Hg(I) and Hg(II) Ions to Amyloid-Beta (Aβ) Peptide Variants Affect their Structure and Aggregation.Chembiochem : a European journal of chemical biology · 2025Article
- Dietary metal chelator, phytochelatin 2, increases selenium and alters metal homeostasis and associated lipid metabolism in the liver.Advances in redox research · 2025Article
- A Narrative Review of Metallomic Studies: Revealing the Toxic Metal Burden in Tobacco Smokers.International journal of molecular sciences · 2025Review
- Development of a Physiologically Based Pharmacokinetic Model for Inorganic Mercury Salts in Rodents and Humans and Its Application in the Derivation of Health-Based Toxicity Metrics.Environmental science & technology · 2025Article
138 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Despite many scientific advances, human exposure to, and intoxication by, toxic metal species continues to occur. Surprisingly, little is understood about the mechanisms by which certain metals and metal-containing species gain entry into target cells. Since there do not appear to be transporters designed specifically for the entry of most toxic metal species into mammalian cells, it has been postulated that some of these metals gain entry into target cells, through the mechanisms of ionic and/or molecular mimicry, at the site of transporters of essential elements and/or molecules. The primary purpose of this review is to discuss the transport of selective toxic metals in target organs and provide evidence supporting a role of ionic and/or molecular mimicry. In the context of this review, molecular mimicry refers to the ability of a metal ion to bond to an endogenous organic molecule to form an organic metal species that acts as a functional or structural mimic of essential molecules at the sites of transporters of those molecules. Ionic mimicry refers to the ability of a cationic form of a toxic metal to mimic an essential element or cationic species of an element at the site of a transporter of that element. Molecular and ionic mimics can also be sub-classified as structural or functional mimics. This review will present the established and putative roles of molecular and ionic mimicry in the transport of mercury, cadmium, lead, arsenic, selenium, and selected oxyanions in target organs and tissues.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.