ArticleVirology journal2005
Stereophysicochemical variability plots highlight conserved antigenic areas in Flaviviruses.
Article in Virology journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed, 17 citations in OpenAlex.
- Small molecule grp94 inhibitors block dengue and Zika virus replication.Antiviral research · 2019Article
- An Approach for a Synthetic CTL Vaccine Design against Zika Flavivirus Using Class I and Class II Epitopes Identified by Computer Modeling.Frontiers in immunology · 2017Article
- AllerTOP v.2--a server for in silico prediction of allergens.Journal of molecular modeling · 2014Article
- Base of the measles virus fusion trimer head receives the signal that triggers membrane fusion.The Journal of biological chemistry · 2012Article
- Physicochemical property consensus sequences for functional analysis, design of multivalent antigens and targeted antivirals.BMC bioinformatics · 2012Article
- PCP consensus sequences of flaviviruses: correlating variance with vector competence and disease phenotype.Journal of molecular biology · 2010Article
- Flavitrack analysis of the structure and function of West Nile non-structural proteins.International journal of bioinformatics research and applications · 2010Article
- Structural analysis of linear and conformational epitopes of allergens.Regulatory toxicology and pharmacology : RTP · 2009Review
- Mechanical stability and differentially conserved physical-chemical properties of titin Ig-domains.Proteins · 2009Article
- Characteristic motifs for families of allergenic proteins.Molecular immunology · 2009Article
- Identification and analysis of conserved sequence motifs in cytochrome P450 family 2. Functional and structural role of a motif 187RFDYKD192 in CYP2B enzymes.The Journal of biological chemistry · 2008Article
- Dynamic interaction of the measles virus hemagglutinin with its receptor signaling lymphocytic activation molecule (SLAM, CD150).The Journal of biological chemistry · 2008Article
- Flavitrack: an annotated database of flavivirus sequences.Bioinformatics (Oxford, England) · 2007Article
- Bioinformatics approaches to classifying allergens and predicting cross-reactivity.Immunology and allergy clinics of North America · 2007Review
- Large-scale analysis of antigenic diversity of T-cell epitopes in dengue virus.BMC bioinformatics · 2006Article
- Determining functionally important amino acid residues of the E1 protein of Venezuelan equine encephalitis virus.Journal of molecular modeling · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundFlaviviruses, which include Dengue (DV) and West Nile (WN), mutate in response to immune system pressure. Identifying escape mutants, variant progeny that replicate in the presence of neutralizing antibodies, is a common way to identify functionally important residues of viral proteins. However, the mutations typically occur at variable positions on the viral surface that are not essential for viral replication. Methods are needed to determine the true targets of the neutralizing antibodies.
resultsStereophysicochemical variability plots (SVPs), 3-D images of protein structures colored according to variability, as determined by our PCPMer program, were used to visualize residues conserved in their physical chemical properties (PCPs) near escape mutant positions. The analysis showed 1) that escape mutations in the flavivirus envelope protein are variable residues by our criteria and 2) two escape mutants found at the same position in many flaviviruses sit above clusters of conserved residues from different regions of the linear sequence. Conservation patterns in T-cell epitopes in the NS3- protease suggest a similar mechanism of immune system evasion.
conclusionThe SVPs add another dimension to structurally defining the binding sites of neutralizing antibodies. They provide a useful aid for determining antigenically important regions and designing vaccines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.