ReviewThe Biochemical journal2005
Exploring the functions of RNA interference pathway proteins: some functions are more RISCy than others?
Review in The Biochemical journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
- Lost and Found: Piwi and Argonaute Pathways in Flatworms.Frontiers in cellular and infection microbiology · 2021Article
- Conservation and diversification of small RNA pathways within flatworms.BMC evolutionary biology · 2017Article
- Article
- Dendronized gold nanoparticles for siRNA delivery.Small (Weinheim an der Bergstrasse, Germany) · 2012Article
- Divergent GW182 functional domains in the regulation of translational silencing.Nucleic acids research · 2011Article
- Article
- Hsp90 regulates the function of argonaute 2 and its recruitment to stress granules and P-bodies.Molecular biology of the cell · 2009Article
- Article
- Schistosoma mansoni: the dicer gene and its expression.Experimental parasitology · 2008Article
- Treasure hunt in an amoeba: non-coding RNAs in Dictyostelium discoideum.Current genetics · 2007Review
- Up-regulation of dicer, a component of the MicroRNA machinery, in prostate adenocarcinoma.The American journal of pathology · 2006Article
- MIWI associates with translational machinery and PIWI-interacting RNAs (piRNAs) in regulating spermatogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Gawky is a component of cytoplasmic mRNA processing bodies required for early Drosophila development.The Journal of cell biology · 2006Article
- An introduction to RNA-mediated gene silencing.Science progress · 2005Review
- Cancer stem cells: the lessons from pre-cancerous stem cells.Journal of cellular and molecular medicineReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
PPD (PAZ Piwi domain) proteins and the Dicer family have been the subjects of intense study over the last 6 years. These proteins have well-established roles in RNAi (RNA interference), a process that relies on siRNAs (small interfering RNAs) or miRNAs (microRNAs) to mediate specificity. The development of techniques for applying RNAi as a laboratory tool and a molecular therapeutic technique has rapidly outpaced our understanding of the biology of this process. However, over the last 2 years, great strides have been made towards elucidating how PPD proteins and Dicer regulate gene-silencing at the pre- and post-transcriptional levels. In addition, evidence is beginning to emerge that suggests that these proteins have additional siRNA-independent roles as cell-cycle regulators. In the present review, we summarize the well-known roles of these two classes of proteins in gene-silencing pathways, as well as explore the evidence for novel roles of PPD and Dicer proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.