ArticleDigestive diseases and sciences2005
Effect of aging on transpyloric flow, gastric emptying, and intragastric distribution in healthy humans--impact on glycemia.
Article in Digestive diseases and sciences, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 56 citations in OpenAlex.
- Oral Multienzyme Supplementation Alters Postprandial Plasma Nutrient Concentrations after a Mixed Meal in Healthy Middle-Aged and Older Adults: A Randomized, Double-Blind, Placebo-Controlled, Crossover Trial.The Journal of nutrition · 2026Trial
- Effect of Vitamin C and Protein Supplementation on Plasma Nitrate and Nitrite Response following Consumption of Beetroot Juice.Nutrients · 2022Trial
- Lesser suppression of energy intake by orally ingested whey protein in healthy older men compared with young controls.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Trial
- Randomized controlled phase Ib study of ghrelin agonist, RM-131, in type 2 diabetic women with delayed gastric emptying: pharmacokinetics and pharmacodynamics.Diabetes care · 2013Trial
- Review
- Ultrasonographic assessment of gastric and gallbladder dynamics in human health and disease.Internal and emergency medicine · 2025Review
- The Effects of a Microbial Enzyme Mixture on Macronutrient Hydrolysis in a Static Simulation of Oro-Gastric Digestion That Models Human Digestive Senescence.Foods (Basel, Switzerland) · 2025Article
- Gastrointestinal Motility Function and Dysfunction in the Elderly Patient: What Are the Effects of Aging?Visceral medicine · 2024Review
- Consumption of hot protein-containing drink accelerates gastric emptying rate and is associated with higher hunger levels in older adults.Temperature (Austin, Tex.) · 2024Article
- Review
- Hypoganglionosis in the gastric antrum causes delayed gastric emptying.Neurogastroenterology and motility · 2020Article
- Gastroparesis post-laparoscopic cholecystectomy in diabetic patients.Updates in surgery · 2017Article
- Understanding the gastrointestinal tract of the elderly to develop dietary solutions that prevent malnutrition.Oncotarget · 2015Review
- Gastric emptying and glycaemia in health and diabetes mellitus.Nature reviews. Endocrinology · 2015Review
- Impact of gastric emptying to the glycemic and insulinemic responses to a 75-g oral glucose load in older subjects with normal and impaired glucose tolerance.Physiological reports · 2014Article
- Gastroparesis and functional dyspepsia: excerpts from the AGA/ANMS meeting.Neurogastroenterology and motility · 2010Review
- The feasibility of serving liquid yoghurt supplemented with probiotic bacteria, Lactobacillus rhamnosus LB 21, and Lactococcus lactis L1A--a pilot study among old people with dementia in a residential care facility.The journal of nutrition, health & aging · 2009Article
- Cachexia and aging: an update based on the Fourth International Cachexia Meeting.The journal of nutrition, health & aging · 2009Article
- Upper gastrointestinal function and glycemic control in diabetes mellitus.World journal of gastroenterology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aims of this study were to evaluate (i) the relationship between transpyloric flow (TF) assessed by Doppler ultrasonography and scintigraphy, (ii) the effects of healthy aging on TF and gastric emptying (GE), and (iii) the relationship between the glycemic response to oral glucose and TF. Ten healthy "young" (7 M, 3 F) and 8 "older" (4 M, 4 F), subjects had simultaneous measurements of TF, GE, and blood glucose after a 600-ml drink (75 g glucose labeled with 20 MBq 99mTc-sulfur colloid) while seated. TF measured by ultrasound was measured during drink ingestion and for 30 min thereafter. GE was measured scintigraphically for 180 min after drink ingestion. Blood glucose was measured before the drink and at regular intervals until 180 min. During drink ingestion, TF was greater (P < 0.05) and GE faster (retention at 60 min: 70.8+/-3.3 vs. 83.8+/-4.6%; P < 0.05) in young compared to older subjects. There was no difference in fasting blood glucose between the two groups but the magnitude of the rise in blood glucose was greater in the young compared to the older subjects; (at 15 min 2.4+/-0.3 vs. 1.5+/-0.5 mmol/L; P < 0.05). In contrast, after 90 min blood glucose concentrations were higher in the older subjects. There were significant relationships between the early blood glucose concentration and both TF (e.g., at 15 min: r = 0.56, P < 0.05) and GE (e.g., at 15 min: r = -0.51, P < 0.05). In conclusion, the results of this study indicate that (i) TF is initially less, and GE slower, in older compared to young subjects; (ii) the initial glycemic response to oral glucose is related to TF; and (iii) measurements of TF by ultrasound and scintigraphy correlate significantly.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.