ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2005
Role of glucocorticoids and cAMP-mediated repression in limiting corticotropin-releasing hormone transcription during stress.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 70 citations in OpenAlex.
- Viral rescue of magnocellular vasopressin cells in adolescent Brattleboro rats ameliorates diabetes insipidus, but not the hypoaroused phenotype.Scientific reports · 2019Article
- Genome-Wide Analysis of Glucocorticoid-Responsive Transcripts in the Hypothalamic Paraventricular Region of Male Rats.Endocrinology · 2019Article
- NRSF-dependent epigenetic mechanisms contribute to programming of stress-sensitive neurons by neonatal experience, promoting resilience.Molecular psychiatry · 2018Article
- A users guide to HPA axis research.Physiology & behavior · 2017Review
- Hyperactivity of Hypothalamic-Pituitary-Adrenal Axis Due to Dysfunction of the Hypothalamic Glucocorticoid Receptor in Sigma-1 Receptor Knockout Mice.Frontiers in molecular neuroscience · 2017Article
- Paraventricular Hypothalamic Mechanisms of Chronic Stress Adaptation.Frontiers in endocrinology · 2016Review
- The Basal NPO crh Fluctuation is Sustained Under Compromised Glucocorticoid Signaling in Diurnal Zebrafish.Frontiers in neuroscience · 2015Article
- Upregulation of CREM/ICER suppresses wound endothelial CRE-HIF-1α-VEGF-dependent signaling and impairs angiogenesis in type 2 diabetes.Disease models & mechanisms · 2015Article
- Novel aspects of glucocorticoid actions.Journal of neuroendocrinology · 2014Review
- Altered gene expression and spine density in nucleus accumbens of adolescent and adult male mice exposed to emotional and physical stress.Developmental neuroscience · 2014Article
- Differential contribution of CBP:CREB binding to corticotropin-releasing hormone expression in the infant and adult hypothalamus.Stress (Amsterdam, Netherlands) · 2014Article
- Transcriptional regulation of episodic glucocorticoid secretion.Molecular and cellular endocrinology · 2013Review
- Maternal deprivation in rats is associated with corticotrophin-releasing hormone (CRH) promoter hypomethylation and enhances CRH transcriptional responses to stress in adulthood.Journal of neuroendocrinology · 2012Article
- The molecular physiology of CRH neurons.Frontiers in neuroendocrinology · 2012Article
- Article
- Emerging roles of epigenetic mechanisms in the enduring effects of early-life stress and experience on learning and memory.Neurobiology of learning and memory · 2011Review
- Stress induces parallel changes in corticotrophin-releasing hormone (CRH) Transcription and nuclear translocation of transducer of regulated cAMP response element-binding activity 2 in hypothalamic CRH neurones.Journal of neuroendocrinology · 2011Article
- Involvement of transducer of regulated cAMP response element-binding protein activity on corticotropin releasing hormone transcription.Endocrinology · 2010Article
- Prolactin induces Egr-1 gene expression in cultured hypothalamic cells and in the rat hypothalamus.Brain research · 2009Article
- Cyclic AMP inducible early repressor mediates the termination of corticotropin releasing hormone transcription in hypothalamic neurons.Cellular and molecular neurobiology · 2009Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The role of glucocorticoids and the repressor isoform of cAMP response element (CRE) modulator (CREM), inducible cAMP early repressor (ICER), in limiting corticotropin-releasing hormone (CRH) transcription during restraint stress were examined in both intact and adrenalectomized rats receiving glucocorticoid replacement. CRH primary transcript, measured by intronic in situ hybridization, increased after 30 min of restraint and returned to basal levels by 90 min, despite the persistent stressor. The decline was independent of circulating glucocorticoids, because adrenalectomized rats displayed an identical pattern. ICER mRNA in the hypothalamic paraventricular nucleus (PVN) increased after 30 min and remained elevated for up to 4 h in a glucocorticoid-independent manner. Western blot and electrophoretic mobility shift assay analyses showed increases in endogenous ICER in the PVN of rats subjected to restraint stress for 3 h. Chromatin immunoprecipitation assays showed the recruitment of CREM by the CRH CRE in conjunction with decreases in RNA polymerase II (Pol II) binding in the PVN region of rats restrained for 3 h. These data show that stress-induced glucocorticoids do not mediate the limitation of CRH transcription. Furthermore, the ability of CREM to bind the CRH CRE and the time relationship between elevated CREM and reduced Pol II recruitment by the CRH promoter suggest that inhibitory isoforms of CREM induced during stress contribute to the decline in CRH gene transcription during persistent stimulation.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.