ArticleProceedings of the National Academy of Sciences of the United States of America2005
Ligand-induced dimerization of Drosophila peptidoglycan recognition proteins in vitro.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
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Who cites it
32 citing papers in PubMed, 104 citations in OpenAlex.
- Pattern recognition receptors in Crustacea: immunological roles under environmental stress.Frontiers in immunology · 2024Review
- Drosophila caspases as guardians of host-microbe interactions.Cell death and differentiation · 2023Review
- Article
- Current Status of Immune Deficiency Pathway inFrontiers in immunology · 2022Review
- Microbiota-derived acetate activates intestinal innate immunity via the Tip60 histone acetyltransferase complex.Immunity · 2021Article
- Accessibility to Peptidoglycan Is Important for the Recognition of Gram-Positive Bacteria in Drosophila.Cell reports · 2019Article
- Peptidoglycan recognition proteins in hematophagous arthropods.Developmental and comparative immunology · 2018Review
- The Peptidoglycan Recognition Proteins PGRPLA and PGRPLB Regulate Anopheles Immunity to Bacteria and Affect Infection by Plasmodium.Journal of innate immunity · 2017Article
- The regulatory isoform rPGRP-LC induces immune resolution via endosomal degradation of receptors.Nature immunology · 2016Article
- The immune signaling pathways of Manduca sexta.Insect biochemistry and molecular biology · 2015Article
- Ligand binding alters dimerization and sequestering of urokinase receptors in raft-mimicking lipid mixtures.Biophysical journal · 2014Article
- The Drosophila IMD pathway in the activation of the humoral immune response.Developmental and comparative immunology · 2014Review
- Peptidoglycan recognition proteins in Drosophila immunity.Developmental and comparative immunology · 2014Review
- Messenger functions of the bacterial cell wall-derived muropeptides.Biochemistry · 2012Review
- Antimicrobial peptide gene induction, involvement of Toll and IMD pathways and defense against bacteria in the red flour beetle, Tribolium castaneum.Results in immunology · 2012Article
- Peptidoglycan recognition proteins: modulators of the microbiome and inflammation.Nature reviews. Immunology · 2011Review
- Epithelial homeostasis and the underlying molecular mechanisms in the gut of the insect model Drosophila melanogaster.Cellular and molecular life sciences : CMLS · 2011Review
- Cleavage of PGRP-LC receptor in the Drosophila IMD pathway in response to live bacterial infection in S2 cells.Self/nonself · 2011Article
- The Drosophila peptidoglycan-recognition protein LF interacts with peptidoglycan-recognition protein LC to downregulate the Imd pathway.EMBO reports · 2011Article
- NF-κB/Rel proteins and the humoral immune responses of Drosophila melanogaster.Current topics in microbiology and immunology · 2011Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Drosophila knockout mutants have placed peptidoglycan recognition proteins (PGRPs) in the two major pathways controlling immune gene expression. We now examine PGRP affinities for peptidoglycan. PGRP-SA and PGRP-LCx are bona fide pattern recognition receptors, and PGRP-SA, the peptidoglycan receptor of the Toll/Dif pathway, has selective affinity for different peptidoglycans. PGRP-LCx, the default peptidoglycan receptor of the Imd/Relish pathway, has strong affinity for all polymeric peptidoglycans tested and for monomeric peptidoglycan. PGRP-LCa does not have affinity for polymeric or monomeric peptidoglycan. Instead, PGRP-LCa can form heterodimers with LCx when the latter is bound to monomeric peptidoglycan. Hence, PGRP-LCa can be said to function as an adaptor, thus adding a new function to a member of the PGRP family.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.