ReviewNaunyn-Schmiedeberg's archives of pharmacology2005
Regulation of TRPM2 channels in neutrophil granulocytes by ADP-ribose: a promising pharmacological target.
Review in Naunyn-Schmiedeberg's archives of pharmacology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
- Update on Calcium Signaling in Cystic Fibrosis Lung Disease.Frontiers in pharmacology · 2021Review
- Review
- Dysregulated Calcium Homeostasis in Cystic Fibrosis Neutrophils Leads to Deficient Antimicrobial Responses.Journal of immunology (Baltimore, Md. : 1950) · 2018Article
- TRPM Family Channels in Cancer.Pharmaceuticals (Basel, Switzerland) · 2018Review
- What is the evidence for the role of TRP channels in inflammatory and immune cells?British journal of pharmacology · 2016Review
- TRPing up reperfusion: neutrophil TRPM2 channels exacerbate necrosis and contractile dysfunction in post-ischaemic myocardium.Cardiovascular research · 2013Article
- The ion channel transient receptor potential melastatin-2 does not play a role in inflammatory mouse models of chronic obstructive pulmonary diseases.Respiratory research · 2012Article
- The ΔC splice-variant of TRPM2 is the hypertonicity-induced cation channel in HeLa cells, and the ecto-enzyme CD38 mediates its activation.The Journal of physiology · 2012Article
- Inhibitors of TRP channels reveal stimulus-dependent differential activation of Ca2+ influx pathways in human neutrophil granulocytes.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- Modulation of TRPM2 by acidic pH and the underlying mechanisms for pH sensitivity.The Journal of general physiology · 2009Article
- Regulation of superoxide production in neutrophils: role of calcium influx.Journal of leukocyte biology · 2008Review
- The Poly(ADP-ribose) polymerase PARP-1 is required for oxidative stress-induced TRPM2 activation in lymphocytes.The Journal of biological chemistry · 2008Article
- Regulation of blood-brain barrier permeability by transient receptor potential type C and type v calcium-permeable channels.Microcirculation (New York, N.Y. : 1994) · 2008Article
- New molecular mechanisms on the activation of TRPM2 channels by oxidative stress and ADP-ribose.Neurochemical research · 2007Review
- Cells move when ions and water flow.Pflugers Archiv : European journal of physiology · 2007Review
- Transient receptor potential (TRP) channels as drug targets.Naunyn-Schmiedeberg's archives of pharmacology · 2006Article
- TRP channels as new pharmacological targets.Naunyn-Schmiedeberg's archives of pharmacology · 2005Article
- Transcriptional regulation and processing increase the functional variability of TRPM channels.Naunyn-Schmiedeberg's archives of pharmacology · 2005Review
- Function and pharmacology of TRPM cation channels.Naunyn-Schmiedeberg's archives of pharmacology · 2005Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
TRPM2 channels play an important role in the activation process of neutrophil granulocytes. One mechanism of TRPM2 channel gating is the binding of intracellular ADP ribose (ADPR) to the Nudix box domain in the C-terminal tail of TRPM2. Intracellular Ca(2+), although not an activator of TRPM2 by its own, significantly enhances TRPM2 gating by ADPR. Stimulation of neutrophil granulocytes with the chemoattractant peptide N-formyl-methionyl-leucyl-phenylalanine (fMLP) induces release of Ca(2+) ions from intracellular stores which in cooperation with endogenous ADPR levels enable Ca(2+) influx through TRPM2. Stimulation of the ectoenzyme CD38, a membrane-associated glycohydrolase with ADPR as main product, and uptake of ADPR into the cell may contribute to the effects of fMLP. Inhibition of ADPR production, of uptake and of binding to TRPM2 are all potential pharmacological principles by which a modulation of neutrophil function may become possible in future.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.