ArticleThe Journal of clinical investigation2005
In hypertension, the kidney is not always the heart of the matter.
Article in The Journal of clinical investigation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 58 citations in OpenAlex.
- Effects of nebivolol versus other antihypertensive drugs on the endothelial dysfunction in patients with essential hypertension.Bioscience reports · 2020Pooled it
- Review
- Fetal Undernutrition Programming, Sympathetic Nerve Activity, and Arterial Hypertension Development.Frontiers in physiology · 2021Review
- A paradoxical increase of force development in saphenous and tail arteries from heterozygous ANO1 knockout mice.Physiological reports · 2020Article
- Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice.The journal of physiological sciences : JPS · 2020Article
- Sex differences in vascular reactivity in mesenteric arteries from a mouse model of acute intermittent porphyria.Molecular genetics and metabolism · 2019Article
- RSK2 contributes to myogenic vasoconstriction of resistance arteries by activating smooth muscle myosin and the NaScience signaling · 2018Article
- The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle.Human molecular genetics · 2018Article
- NMR insight into myosin-binding subunit coiled-coil structure reveals binding interface with protein kinase G-Iα leucine zipper in vascular function.The Journal of biological chemistry · 2017Article
- The roles of sensitization and neuroplasticity in the long-term regulation of blood pressure and hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2015Review
- Vascular Type 1A Angiotensin II Receptors Control BP by Regulating Renal Blood Flow and Urinary Sodium Excretion.Journal of the American Society of Nephrology : JASN · 2015Article
- Role of smooth muscle cell mineralocorticoid receptor in vascular tone.Pflugers Archiv : European journal of physiology · 2015Article
- Regulation of vascular tone and arterial blood pressure: role of chloride transport in vascular smooth muscle.Pflugers Archiv : European journal of physiology · 2015Review
- Disruption of vascular Ca2+-activated chloride currents lowers blood pressure.The Journal of clinical investigation · 2014Article
- Regulation of intraocular pressure by soluble and membrane guanylate cyclases and their role in glaucoma.Frontiers in molecular neuroscience · 2014Review
- Smooth muscle cell mineralocorticoid receptors: role in vascular function and contribution to cardiovascular disease.Pflugers Archiv : European journal of physiology · 2013Review
- Direct contribution of vascular mineralocorticoid receptors to blood pressure regulation.Clinical and experimental pharmacology & physiology · 2013Review
- Increased constrictor tone induced by ouabain treatment in rats.Journal of cardiovascular pharmacology · 2013Article
- Mineralocorticoid receptors in vascular disease: connecting molecular pathways to clinical implications.Current atherosclerosis reports · 2013Review
- Assessing murine resistance artery function using pressure myography.Journal of visualized experiments : JoVE · 2013Article
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1 author at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
Blood pressure abnormalities are thought to originate from intrinsic changes in the kidney, a concept that has been largely unchallenged for more than 4 decades. However, recent molecular, cellular, and transgenic mouse studies support an alternative hypothesis: primary abnormalities in vascular cell function can also directly cause abnormalities of blood pressure. In this issue of the JCI, Crowley and coworkers describe the application of an elegant cross-renal transplant model to type 1A angiotensin (AT(1A)) receptor-deficient mice and their wild-type littermates to explore the relative contributions of renal and extrarenal tissues to the low blood pressure seen in the AT(1A) receptor-deficient animals. Their studies further support the emerging paradigm that primary abnormalities of the vasculature can make unique, nonredundant contributions to blood pressure regulation; the findings have potentially important implications for the ways we diagnose and treat blood pressure diseases in humans.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.