ArticleThe Journal of clinical investigation2005
To live or die: a critical decision for the lung.
Article in The Journal of clinical investigation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
6 citing papers in PubMed.
- Review
- Alcohol worsens acute lung injury by inhibiting alveolar sodium transport through the adenosine A1 receptor.PloS one · 2012Article
- Epithelial cell death is an important contributor to oxidant-mediated acute lung injury.American journal of respiratory and critical care medicine · 2011Article
- Consequences of hyperoxia and the toxicity of oxygen in the lung.Nursing research and practice · 2011Article
- Coenzyme Q1 redox metabolism during passage through the rat pulmonary circulation and the effect of hyperoxia.Journal of applied physiology (Bethesda, Md. : 1985) · 2008Article
- Hyperoxic acute lung injury and ventilator-induced/associated lung injury: new insights into intracellular signaling pathways.Critical care (London, England) · 2007Article
Corrections and comments
- Comment on
Authors and funding
2 authors.
Funding
Abstract
Every cell in the body expresses a set of proteins designed to trigger permeabilization of the mitochondria and cell death. Inactivation or inappropriate triggering of these pathways is increasingly recognized as a contributor to human disease. A study in this issue of the JCI demonstrates that IL-6 exerts its protective effect against the development of lung injury following exposure of mice to 95% O(2) by increasing the expression of a Bcl-2-related protein, A1. This protein acts to prevent mitochondrial membrane permeabilization and cell death following exposure to hyperoxia. The data in this study lend support to the hypothesis that inappropriate triggering of cell-death pathways may contribute to the development of hyperoxic pulmonary edema, lung injury, and respiratory failure.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.