ArticleThe Journal of clinical investigation2005
The pathophysiology of autoimmune blistering diseases.
Article in The Journal of clinical investigation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
27 citing papers in PubMed, 86 citations in OpenAlex.
- The complement receptor C5aR2 regulates neutrophil activation and function contributing to neutrophil-driven epidermolysis bullosa acquisita.Frontiers in immunology · 2023Article
- May Bacterial Infections Trigger Bullous Pemphigoid? Case Report and Review of Literature.Microorganisms · 2021Article
- Coagulation and Skin Autoimmunity.Frontiers in immunology · 2019Review
- Skin Barrier and Autoimmunity-Mechanisms and Novel Therapeutic Approaches for Autoimmune Blistering Diseases of the Skin.Frontiers in immunology · 2019Review
- Bullous Pemphigoid IgG Induces Cell Dysfunction and Enhances the Motility of Epidermal Keratinocytes via Rac1/Proteasome Activation.Frontiers in immunology · 2019Article
- Itch, eosinophils, and autoimmunity: a novel murine model of bullous pemphigoid.The Journal of investigative dermatology · 2015Article
- Vitamin D and skeletal health in autoimmune bullous skin diseases: a case control study.Orphanet journal of rare diseases · 2015Article
- Activation of Blood Coagulation in Two Prototypic Autoimmune Skin Diseases: A Possible Link with Thrombotic Risk.PloS one · 2015Article
- Prothrombotic state and impaired fibrinolysis in bullous pemphigoid, the most frequent autoimmune blistering disease.Clinical and experimental immunology · 2013Article
- Activation of coagulation in bullous pemphigoid and other eosinophil-related inflammatory skin diseases.Clinical and experimental immunology · 2011Article
- The Roles of ADAMs Family Proteinases in Skin Diseases.Enzyme research · 2011Article
- Mechanisms mediating the vesicant actions of sulfur mustard after cutaneous exposure.Toxicological sciences : an official journal of the Society of Toxicology · 2010Review
- Doxycycline loaded poly(ethylene glycol) hydrogels for healing vesicant-induced ocular wounds.Biomaterials · 2010Article
- Blockade of autoantibody-initiated tissue damage by using recombinant fab antibody fragments against pathogenic autoantigen.The American journal of pathology · 2010Article
- Radio-induced bullous pemphigoid.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2010Article
- Coagulation activation in autoimmune bullous diseases.Clinical and experimental immunology · 2009Article
- Shedding of collagen XVII/BP180 in skin depends on both ADAM10 and ADAM9.The Journal of biological chemistry · 2009Article
- Differential gene expression profiling of mouse skin after sulfur mustard exposure: Extended time response and inhibitor effect.Toxicology and applied pharmacology · 2009Article
- The desmosome and pemphigus.Histochemistry and cell biology · 2008Review
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1 author at 1 institution in 1 country.
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Abstract
Knowledge of the pathophysiology of immunobullous diseases has been advanced by the demonstration that passive transfer of antibodies against skin autoantigens can induce blisters in experimental animals with clinical, histologic, and immunopathologic features similar to those seen in human patients. In this issue of the JCI, Liu et al. extend their earlier observations regarding an experimental murine model of bullous pemphigoid by showing that the plasminogen/plasmin signaling cascade synergizes with MMP-9 during the early phase of antibody-induced blister formation in vivo. In a separate study, Sitaru et al. show for the first time to my knowledge that passive transfer of experimental antibodies against type VII collagen create subepidermal blisters in mice that mimic those seen in patients with epidermolysis bullosa acquisita (see the related article beginning on page 870). While the articles by Liu, Sitaru, and their colleagues identify pathways of inflammation and tissue injury that, if interrupted, may abrogate blister formation, in a third study, Payne et al. utilized phage display technologies to isolate human anti-desmoglein monoclonal antibodies from a patient with pemphigus vulgaris and show that such antibodies have restricted patterns of heavy and light chain gene usage - findings suggesting that autoantibodies may represent an additional target for therapeutic interventions in patients with immunobullous diseases (see the related article beginning on page 888).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.