ReviewThe Journal of clinical investigation2005
Melanoma genetics and the development of rational therapeutics.
Review in The Journal of clinical investigation, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 63 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
63 citing papers in PubMed, 3 syntheses or guidelines pooled it, 188 citations in OpenAlex.
- Antimelanoma potential of natural compounds derived from plants: a systematic review of in vivo studies of B16 melanoma and its sublines.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2025Pooled it
- Clinical Characteristics and Prognostic Significance of TERT Promoter Mutations in Cancer: A Cohort Study and a Meta-Analysis.PloS one · 2016Pooled it
- Gene signature of the metastatic potential of cutaneous melanoma: too much for too little?Clinical & experimental metastasis · 2010Pooled it
- Highly multiplexed 3D profiling of cell states and immune niches in human tumors.Nature methods · 2025Article
- Review
- The Emerging Burden of Genetic Instability and Mutation in Melanoma: Role of Molecular Mechanisms.Cancers · 2022Article
- CD200 ectodomain shedding into the tumor microenvironment leads to NK cell dysfunction and apoptosis.The Journal of clinical investigation · 2022Article
- Micro-endoscopy for Live Small Animal Fluorescent Imaging.Advances in experimental medicine and biology · 2021Article
- ROS Pleiotropy in Melanoma and Local Therapy with Physical Modalities.Oxidative medicine and cellular longevity · 2021Review
- The challenge of primary gastric melanoma: a systematic review.Melanoma management · 2020Review
- Review
- MiRNA therapeutics based on logic circuits of biological pathways.BMC bioinformatics · 2019Article
- Familial Melanoma: Diagnostic and Management Implications.Dermatology practical & conceptual · 2019Article
- ROCK inhibitor enhances the growth and migration of BRAF-mutant skin melanoma cells.Cancer science · 2018Article
- Chk1 inhibition as a novel therapeutic strategy in melanoma.Oncotarget · 2018Article
- Article
- Mutational status of naevus-associated melanomas.The British journal of dermatology · 2015Article
- Primary Melanoma of Infra Temporal Fossa: A Case Report.Indian journal of surgical oncology · 2015Article
- Update in genetic susceptibility in melanoma.Annals of translational medicine · 2015Review
- NUAK2 Amplification Coupled with PTEN Deficiency Promotes Melanoma Development via CDK Activation.Cancer research · 2015Article
3 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Melanoma is a cancer of the neural crest-derived cells that provide pigmentation to skin and other tissues. Over the past 4 decades, the incidence of melanoma has increased more rapidly than that of any other malignancy in the United States. No current treatments substantially enhance patient survival once metastasis has occurred. This review focuses on recent insights into melanoma genetics and new therapeutic approaches being developed based on these advances.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.