ReviewNature reviews. Immunology2005
Inducible lymphoid tissues in the adult gut: recapitulation of a fetal developmental pathway?
Review in Nature reviews. Immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 126 citations in OpenAlex.
- An SSTR2-somatostatin chemotactic axis drives T cell progenitor homing to the intestines.Nature immunology · 2025Article
- Lymph node or lymphoid aggregate? Impact on cancer resection quality, clinical prognosis, and tumor staging.Histology and histopathology · 2025Review
- From bench to bedside: an interdisciplinary journey through the gut-lung axis with insights into lung cancer and immunotherapy.Frontiers in immunology · 2024Review
- The interaction between intestinal microenvironment and stroke.CNS neuroscience & therapeutics · 2023Review
- Intestinal fibroblastic reticular cell niches control innate lymphoid cell homeostasis and function.Nature communications · 2022Article
- An integrin αEβ7-dependent mechanism of IgA transcytosis requires direct plasma cell contact with intestinal epithelium.Mucosal immunology · 2021Article
- Spatial distribution of LTi-like cells in intestinal mucosa regulates type 3 innate immunity.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Elucidation of the Effects of a Current X-SCID Therapy on Intestinal Lymphoid Organogenesis Using an In Vivo Animal Model.Cellular and molecular gastroenterology and hepatology · 2020Article
- The interaction of intestinal microbiota and innate lymphoid cells in health and disease throughout life.Immunology · 2020Review
- Aligning the Paradoxical Role of Vitamin D in Gastrointestinal Immunity.Trends in endocrinology and metabolism: TEM · 2019Review
- Vitamin A and vitamin D regulate the microbial complexity, barrier function, and the mucosal immune responses to ensure intestinal homeostasis.Critical reviews in biochemistry and molecular biology · 2019Review
- The Development of Steady-State Activation Hubs between Adult LTi ILC3s and Primed Macrophages in Small Intestine.Journal of immunology (Baltimore, Md. : 1950) · 2017Article
- Review
- Group 3 Innate Lymphoid Cells: Communications Hubs of the Intestinal Immune System.Frontiers in immunology · 2017Review
- The formation and function of tertiary lymphoid follicles in chronic pulmonary inflammation.Immunology · 2016Review
- TIR-Domain-Containing Adapter-Inducing Interferon-Journal of clinical & cellular immunology · 2016Article
- Dynamics of HIV infection in lymphoid tissue network.Journal of mathematical biology · 2016Article
- Article
- Innate lymphoid cells. Innate lymphoid cells: a new paradigm in immunology.Science (New York, N.Y.) · 2015Review
- Identification and distribution of developing innate lymphoid cells in the fetal mouse intestine.Nature immunology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The intestinal immune system faces an extraordinary challenge from the large numbers of commensal bacteria and potential pathogens that are restrained by only a single layer of epithelial cells. Here, I discuss evidence that the intestinal immune system develops an extensive network of inducible, reversible lymphoid tissues that contributes to the vital equilibrium between the gut and the bacterial flora. I propose that this network is induced by cryptopatches, which are small clusters of dendritic cells and lymphoid cells that are identical to fetal inducers of lymph-node and Peyer's-patch development.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.