Evidence map›Paper›PMID 15841099›Full record

ReviewNature reviews. Immunology2005

A new self: MHC-class-I-independent natural-killer-cell self-tolerance.

Vinay Kumar, Megan E McNerney

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Immunology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 68 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
68citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

68 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Review
  6. Review
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  9. Review
  10. Article
  11. Review
  12. Recognition ofInnate immunity · 2023
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Rheumatoid Arthritis Susceptibility Is Associated with theReports of biochemistry & molecular biology · 2021
    Article
  18. Review
  19. Review
  20. Article

8 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Vinay KumarDepartment of Pathology, Committee on Immunology, University of Chicago, 5841 South Maryland Avenue, S-315 MC3083, Chicago, Illinois 60637, USA. vkumar@bsd.uchicago.edu
Megan E McNerney

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A fundamental tenet of the immune system is the requirement for lymphocytes to respond to transformed or infected cells while remaining tolerant of normal cells. Natural killer (NK) cells discriminate between self and non-self by monitoring the expression of MHC class I molecules. According to the 'missing-self' hypothesis, cells that express self-MHC class I molecules are protected from NK cells, but those that lack this self-marker are eliminated by NK cells. Recent work has revealed that there is another system of NK-cell inhibition, which is independent of MHC class I molecules. Newly discovered NK-cell inhibitory receptors that have non-MHC-molecule ligands broaden the definition of self as seen by NK cells.

Indexed as

AnimalsAntigens, NeoplasmAutoimmunityCell Adhesion MoleculesHistocompatibility Antigens Class IHumansKiller Cells, NaturalLectinsReceptors, AntigenSelf ToleranceSialic AcidsAntigens, NeoplasmCell Adhesion MoleculesHistocompatibility Antigens Class ILectinsReceptors, AntigenSialic Acids

Identifiers

PMID15841099

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.