ArticleVirology2005
Cells of human aminopeptidase N (CD13) transgenic mice are infected by human coronavirus-229E in vitro, but not in vivo.
Article in Virology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 39 citations in OpenAlex.
- Cerebral ischemic and hemorrhagic complications of coronavirus disease 2019.International journal of stroke : official journal of the International Stroke Society · 2020Pooled it
- Exploring coronavirus cell entry with functional viromics.Journal of virology · 2026Review
- The age-dependent neuroglial interaction with peripheral immune cells in coronavirus-induced neuroinflammation with a special emphasis on COVID-19.Biogerontology · 2025Review
- Review
- Biological and Psychological Factors Determining Neuropsychiatric Outcomes in COVID-19.Current psychiatry reports · 2021Review
- Neurological manifestations of COVID-19: with emphasis on Iranian patients.Journal of neurovirology · 2021Review
- Coronavirus Receptors as Immune Modulators.Journal of immunology (Baltimore, Md. : 1950) · 2021Review
- Neurological and Neuropsychiatric Impacts of COVID-19 Pandemic.The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques · 2021Review
- How SARS-Cov-2 can involve the central nervous system. A systematic analysis of literature of the department of human neurosciences of Sapienza University, Italy.Journal of clinical neuroscience : official journal of the Neurosurgical Society of Australasia · 2020Review
- Management of epigenomic networks entailed in coronavirus infections and COVID-19.Clinical epigenetics · 2020Review
- Unraveling the Possible Routes of SARS-COV-2 Invasion into the Central Nervous System.Current treatment options in neurology · 2020Review
- Potential of SARS-CoV-2 to Cause CNS Infection: Biologic Fundamental and Clinical Experience.Frontiers in neurology · 2020Review
- Human Coronaviruses and Other Respiratory Viruses: Underestimated Opportunistic Pathogens of the Central Nervous System?Viruses · 2019Review
- Resistance to coronavirus infection in amino peptidase N-deficient pigs.Transgenic research · 2019Article
- Three Main Inducers of Alphacoronavirus Infection of Enterocytes: Sialic Acid, Proteases, and Low pH.Intervirology · 2018Review
- Coronaviruses and the human airway: a universal system for virus-host interaction studies.Virology journal · 2016Review
- CD13 mediates phagocytosis in human monocytic cells.Journal of leukocyte biology · 2015Article
- Human coronaviruses: viral and cellular factors involved in neuroinvasiveness and neuropathogenesis.Virus research · 2014Review
- Neuroinvasive and neurotropic human respiratory coronaviruses: potential neurovirulent agents in humans.Advances in experimental medicine and biology · 2014Review
- Renin-angiotensin system in human coronavirus pathogenesis.Future virology · 2010Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
Aminopeptidase N, or CD13, is a receptor for serologically related coronaviruses of humans, pigs, and cats. A mouse line transgenic for the receptor of human coronavirus-229E (HCoV-229E) was created using human APN (hAPN) cDNA driven by a hAPN promoter. hAPN-transgenic mice expressed hAPN mRNA in the kidney, small intestine, liver, and lung. hAPN protein was specifically expressed on epithelial cells of the proximal convoluted renal tubules, bronchi, alveolar sacs, and intestinal villi. The hAPN expression pattern within transgenic mouse tissues matched that of mouse APN and was similar in mice heterozygous or homozygous for the transgene. Primary embryonic cells and bone marrow dendritic cells derived from hAPN-transgenic mice also expressed hAPN protein. Although hAPN-transgenic mice were resistant to HCoV-229E in vivo, primary embryonic cells and bone marrow dendritic cells were infected in vitro. hAPN-transgenic mice are valuable as a source of primary mouse cells expressing hAPN. This hAPN-transgenic line will also be used for crossbreeding experiments with other knockout, immune deficient, or transgenic mice to identify factors, in addition to hAPN, that are required for HCoV-229E infection.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.