ArticleVirology journal2005
Amphotropic murine leukaemia virus envelope protein is associated with cholesterol-rich microdomains.
Article in Virology journal, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed, 26 citations in OpenAlex.
- High-throughput imaging method for direct assessment of GM1 ganglioside levels in mammalian cells.Data in brief · 2016Article
- Intracellular trafficking of hybrid gene delivery vectors.Journal of controlled release : official journal of the Controlled Release Society · 2015Article
- The cytoplasmic tail of retroviral envelope glycoproteins.Progress in molecular biology and translational science · 2015Review
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- The Role of Lipids in Retrovirus Replication.Viruses · 2010Article
- A novel mechanism of sequestering fibroblast growth factor 2 by glypican in lipid rafts, allowing skeletal muscle differentiation.Molecular and cellular biology · 2010Article
- Murine leukemia virus glycosylated Gag (gPr80gag) facilitates interferon-sensitive virus release through lipid rafts.Proceedings of the National Academy of Sciences of the United States of America · 2010Article
- Lipids and membrane microdomains in HIV-1 replication.Virus research · 2009Review
- Cholesterol Supplementation During Production Increases the Infectivity of Retroviral and Lentiviral Vectors Pseudotyped with the Vesicular Stomatitis Virus Glycoprotein (VSV-G).Biochemical engineering journal · 2009Article
- Article
- Retroviral vectors for clinical immunogene therapy are stable for up to 9 years.Cancer gene therapy · 2008Article
- Equine infectious anemia virus entry occurs through clathrin-mediated endocytosis.Journal of virology · 2008Article
- Arenavirus entry occurs through a cholesterol-dependent, non-caveolar, clathrin-mediated endocytic mechanism.Virology · 2007Article
- Molecular and phylogenetic analyses of a new amphotropic murine leukemia virus (MuLV-1313).Virology journal · 2006Article
- Caveolin-1 interacts with the Gag precursor of murine leukaemia virus and modulates virus production.Virology journal · 2006Article
- Amphotropic murine leukemia virus is preferentially attached to cholesterol-rich microdomains after binding to mouse fibroblasts.Virology journal · 2006Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCholesterol-rich microdomains like lipid rafts were recently identified as regions within the plasma membrane, which play an important role in the assembly and budding of different viruses, e.g., measles virus and human immunodeficiency virus. For these viruses association of newly synthesized viral proteins with lipid rafts has been shown.
resultsHere we provide evidence for the association of the envelope protein (Env) of the 4070A isolate of amphotropic murine leukaemia virus (A-MLV) with lipid rafts. Using density gradient centrifugation and immunocytochemical analyses, we show that Env co-localizes with cholesterol, ganglioside GM1 and caveolin-1 in these specific regions of the plasma membrane.
conclusionsThese results show that a large amount of A-MLV Env is associated with lipid rafts and suggest that cholesterol-rich microdomains are used as portals for the exit of A-MLV.
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