ArticleJournal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology2005
Mechanisms of postinhibitory rebound and its modulation by serotonin in excitatory swim motor neurons of the medicinal leech.
Article in Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Characterizing optogenetically mediated rebound effects in anaesthetized mouse primary visual cortex.The Journal of physiology · 2025Article
- Error Function Optimization to Compare Neural Activity and Train Blended Rhythmic Networks.Brain sciences · 2024Article
- Pairing cellular and synaptic dynamics into building blocks of rhythmic neural circuits. A tutorial.Frontiers in network physiology · 2024Article
- Postinhibitory excitation in motoneurons can be facilitated by hyperpolarization-activated inward currents: A simulation study.PLoS computational biology · 2024Article
- Neuron matters: neuromodulation with electromagnetic stimulation must consider neurons as dynamic identities.Journal of neuroengineering and rehabilitation · 2022Review
- Multiple intrinsic membrane properties are modulated in a switch from single- to dual-network activity.Journal of neurophysiology · 2022Article
- Altered neocortical oscillations and cellular excitability in an in vitro Wwox knockout mouse model of epileptic encephalopathy.Neurobiology of disease · 2021Article
- Effects of calcium-activated potassium channel modulators on afterhyperpolarizing potentials in identified motor and mechanosensory neurons of the medicinal leech.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2021Article
- Circuit Stability to Perturbations Reveals Hidden Variability in the Balance of Intrinsic and Synaptic Conductances.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Serotonin in Animal Cognition and Behavior.International journal of molecular sciences · 2020Review
- Bifurcations of Limit Cycles in a Reduced Model of the Xenopus Tadpole Central Pattern Generator.Journal of mathematical neuroscience · 2018Article
- Switchable slow cellular conductances determine robustness and tunability of network states.PLoS computational biology · 2018Article
- Circuit feedback increases activity level of a circuit input through interactions with intrinsic properties.Journal of neurophysiology · 2017Article
- 9-Phenanthrol modulates postinhibitory rebound and afterhyperpolarizing potentials in an excitatory motor neuron of the medicinal leech.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2017Article
- Modelling Feedback Excitation, Pacemaker Properties and Sensory Switching of Electrically Coupled Brainstem Neurons Controlling Rhythmic Activity.PLoS computational biology · 2016Article
- A positive feedback at the cellular level promotes robustness and modulation at the circuit level.Journal of neurophysiology · 2015Article
- Riluzole suppresses postinhibitory rebound in an excitatory motor neuron of the medicinal leech.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2014Article
- Convergent rhythm generation from divergent cellular mechanisms.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- The activity of leech motoneurons during motor patterns is regulated by intrinsic properties and synaptic inputs.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2012Article
- Low-threshold calcium currents contribute to locomotor-like activity in neonatal mice.Journal of neurophysiology · 2012Article
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Authors and funding
4 authors.
Funding
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Abstract
Postinhibitory rebound (PIR) is defined as membrane depolarization occurring at the offset of a hyperpolarizing stimulus and is one of several intrinsic properties that may promote rhythmic electrical activity. PIR can be produced by several mechanisms including hyperpolarization-activated cation current (I(h)) or de-inactivation of depolarization-activated inward currents. Excitatory swim motor neurons in the leech exhibit PIR in response to injected current pulses or inhibitory synaptic input. Serotonin, a potent modulator of leech swimming behavior, increases the peak amplitude of PIR and decreases its duration, effects consistent with supporting rhythmic activity. In this study, we performed current clamp experiments on dorsal excitatory cell 3 (DE-3) and ventral excitatory cell 4 (VE-4). We found a significant difference in the shape of PIR responses expressed by these two cell types in normal saline, with DE-3 exhibiting a larger prolonged component. Exposing motor neurons to serotonin eliminated this difference. Cs+ had no effect on PIR, suggesting that I(h) plays no role. PIR was suppressed completely when low Na+ solution was combined with Ca2+-channel blockers. Our data support the hypothesis that PIR in swim motor neurons is produced by a combination of low-threshold Na+ and Ca2+ currents that begin to activate near -60 mV.
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