ReviewMolecular psychiatry2005
Genetic or epigenetic difference causing discordance between monozygotic twins as a clue to molecular basis of mental disorders.
Review in Molecular psychiatry, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genetics of monozygotic twins reveals the impact of environmental sensitivity on psychiatric and neurodevelopmental phenotypes.Nature human behaviour · 2025Pooled it
- Shin Ihda's "manifestation model of mood disorders" based on situation theory and twin studies.PCN reports : psychiatry and clinical neurosciences · 2025Review
- Technical strategy for monozygotic twin discrimination by single-nucleotide variants.International journal of legal medicine · 2024Article
- Biallelic mutations of TTC12 and TTC21B were identified in Chinese patients with multisystem ciliopathy syndromes.Human genomics · 2022Article
- Deciphering microbiome and neuroactive immune gene interactions in schizophrenia.Neurobiology of disease · 2020Review
- Influence of adjuvant Coenzyme Q10 on inflammatory and oxidative stress biomarkers in patients with bipolar disorders during the depressive episode.Molecular biology reports · 2019Article
- Somatic mutations in the human brain: implications for psychiatric research.Molecular psychiatry · 2019Review
- RNA sequencing of identical twins discordant for autism reveals blood-based signatures implicating immune and transcriptional dysregulation.Molecular autism · 2019Article
- Somatic mutations in disorders with disrupted brain connectivity.Experimental & molecular medicine · 2016Review
- Failure to Identify Somatic Mutations in Monozygotic Twins Discordant for Schizophrenia by Whole Exome Sequencing.Chinese medical journal · 2016Article
- Clashing Diagnostic Approaches: DSM-ICD Versus RDoC.Annual review of clinical psychology · 2016Review
- Neuronal copper homeostasis susceptibility by genetic defects in dysbindin, a schizophrenia susceptibility factor.Human molecular genetics · 2015Article
- Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center.Neural development · 2015Article
- Enrichment of cis-regulatory gene expression SNPs and methylation quantitative trait loci among bipolar disorder susceptibility variants.Molecular psychiatry · 2013Article
- Proteomic analysis of lymphoblastoid cells derived from monozygotic twins discordant for bipolar disorder: a preliminary study.PloS one · 2013Article
- Genetic, environmental and stochastic factors in monozygotic twin discordance with a focus on epigenetic differences.BMC medicine · 2012Review
- Evidence-based psychiatric genetics, AKA the false dichotomy between common and rare variant hypotheses.Molecular psychiatry · 2012Review
- Clinical applications of schizophrenia genetics: genetic diagnosis, risk, and counseling in the molecular era.The application of clinical genetics · 2012Article
- DNA methylation in schizophrenia: progress and challenges of epigenetic studies.Genome medicine · 2012Review
- Histone deacetylases and mood disorders: epigenetic programming in gene-environment interactions.CNS neuroscience & therapeutics · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Classical twin research focused on differentiating genetic factors from environmental factors by comparing the concordance rate between monozygotic (MZ) and dizygotic twins. On the other hand, recent twin research tries to identify genetic or epigenetic differences between MZ twins discordant for mental disorders. There are a number of reports of MZ twins discordant for genetic disorders caused by genetic or epigenetic differences of known pathogenic genes. In the case of mental disorder research, for which the causative gene has not been established yet, we are trying to identify the 'pathogenic gene' by comprehensive analysis of genetic or epigenetic difference between discordant MZ twins. To date, no compelling evidence suggesting such difference between MZ twins has been reported. However, if the genetic or epigenetic difference responsible for the discordant phenotype is found, it will have impact on the biology of mental disorder, in which few conclusive molecular genetic evidences have been obtained.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.