ReviewOncogene2005
Cell-cycle control in Caenorhabditis elegans: how the worm moves from G1 to S.
Review in Oncogene, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
16 citing papers in PubMed.
- Revealing a coherent cell-state landscape across single-cell datasets with CONCORD.Nature biotechnology · 2026Article
- Revealing a coherent cell state landscape across single cell datasets with CONCORD.bioRxiv : the preprint server for biology · 2025Article
- An Emerging Animal Model for Querying the Role of Whole Genome Duplication in Development, Evolution, and Disease.Journal of developmental biology · 2023Review
- Dissecting the Genetic and Etiological Causes of Primary Microcephaly.Frontiers in neurology · 2020Review
- A model of the regulatory network involved in the control of the cell cycle and cell differentiation in the Caenorhabditis elegans vulva.BMC bioinformatics · 2015Article
- The C. elegans NR4A nuclear receptor gene nhr-6 promotes cell cycle progression in the spermatheca lineage.Developmental dynamics : an official publication of the American Association of Anatomists · 2015Article
- Boolean genetic network model for the control of C. elegans early embryonic cell cycles.Biomedical engineering online · 2013Article
- DYRK1A protein kinase promotes quiescence and senescence through DREAM complex assembly.Genes & development · 2011Article
- Cyclin E and Cdk2 control GLD-1, the mitosis/meiosis decision, and germline stem cells in Caenorhabditis elegans.PLoS genetics · 2011Article
- 14-3-3Gamma inhibition of MDMX-mediated p21 turnover independent of p53.The Journal of biological chemistry · 2011Article
- Spindle assembly checkpoint genes reveal distinct as well as overlapping expression that implicates MDF-2/Mad2 in postembryonic seam cell proliferation in Caenorhabditis elegans.BMC cell biology · 2010Article
- The ancient function of RB-E2F pathway: insights from its evolutionary history.Biology direct · 2010Article
- An overview of stress response and hypometabolic strategies in Caenorhabditis elegans: conserved and contrasting signals with the mammalian system.International journal of biological sciences · 2010Review
- Mechanisms controlling cell cycle exit upon terminal differentiation.Current opinion in cell biology · 2007Review
- Cell size checkpoint control by the retinoblastoma tumor suppressor pathway.PLoS genetics · 2006Article
- Cyclin D regulation of a sexually dimorphic asymmetric cell division.Developmental cell · 2005Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The nematode Caenorhabditis elegans offers a powerful model system to study cell division control during animal development. Progress from the one-cell zygote to adult stage follows a nearly invariant pattern of divisions. This, combined with a transparent body and efficient genetics, allows for sensitive identification and quantitative analysis of cell-cycle mutants. Nearly all G1 control genes identified in C. elegans have mammalian homologs. Examples include a D-type cyclin and CDK4/6-related kinase, a member of the retinoblastoma protein family and CDK inhibitors of the Cip/Kip family. Genetic studies have placed the currently known G1 regulators into pathways similar to those in mammals. Together, this validates the use of C. elegans in identifying additional regulators of cell-cycle entry and exit. For instance, we recently found that the CDC-14 phosphatase promotes maintenance of the quiescent state. Here, we describe cell-cycle control as an integral part of C. elegans development, summarize current knowledge of G1 control genes in the worm, compare the results with those obtained in other species, and discuss the possible implications of cell-cycle studies in C. elegans for higher organisms, including humans.
Indexed as
Identifiers
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.