ArticleJournal of bacteriology2005
A glimpse into the expanded genome content of Vibrio cholerae through identification of genes present in environmental strains.
Article in Journal of bacteriology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
32 citing papers in PubMed, 61 citations in OpenAlex.
- Non-serogroup O1/O139 agglutinable Vibrio cholerae: a phylogenetically and genealogically neglected yet emerging potential pathogen of clinical relevance.Archives of microbiology · 2022Review
- Genomic contextualisation of ancient DNA molecular data from an Argentinian fifth pandemicMicrobial genomics · 2021Article
- Review
- Cell Death Signaling Pathway Induced by Cholix Toxin, a Cytotoxin and eEF2 ADP-Ribosyltransferase Produced byToxins · 2020Review
- Standardized bacteriophage purification for personalized phage therapy.Nature protocols · 2020Article
- Identification of cholix toxin gene inIranian journal of microbiology · 2020Article
- Crystal Structure of Exotoxin A fromToxins · 2020Article
- DNA-uptake pili of Vibrio cholerae are required for chitin colonization and capable of kin recognition via sequence-specific self-interaction.Nature microbiology · 2019Article
- Modulation of CrbS-Dependent Activation of the Acetate Switch in Vibrio cholerae.Journal of bacteriology · 2018Article
- A Putative Acetylation System in Vibrio cholerae Modulates Virulence in Arthropod Hosts.Applied and environmental microbiology · 2018Article
- Environmental role of pathogenic traits inJournal of bacteriology · 2018Article
- Article
- The Father, Son and Cholix Toxin: The Third Member of the DT Group Mono-ADP-Ribosyltransferase Toxin Family.Toxins · 2015Review
- ADP-Ribosylargininyl reaction of cholix toxin is mediated through diffusible intermediates.BMC biochemistry · 2014Article
- Novel cholix toxin variants, ADP-ribosylating toxins in Vibrio cholerae non-O1/non-O139 strains, and their pathogenicity.Infection and immunity · 2013Article
- The 1.8 Å cholix toxin crystal structure in complex with NAD+ and evidence for a new kinetic model.The Journal of biological chemistry · 2012Article
- Conserved small RNAs govern replication and incompatibility of a diverse new plasmid family from marine bacteria.Nucleic acids research · 2011Article
- Identification of compounds with bioactivity against the nematode Caenorhabditis elegans by a screen based on the functional genomics of the marine bacterium Pseudoalteromonas tunicata D2.Applied and environmental microbiology · 2010Article
- Initial characterization of an immunotoxin constructed from domains II and III of cholera exotoxin.Cancer immunology, immunotherapy : CII · 2010Article
- Defining the mode of action of tetramic acid antibacterials derived from Pseudomonas aeruginosa quorum sensing signals.Journal of the American Chemical Society · 2009Article
Corrections and comments
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Authors and funding
5 authors at 4 institutions in 1 country.
Funding
Abstract
Vibrio cholerae has multiple survival strategies which are reflected both in its broad distribution in many aquatic environments and its high genotypic diversity. To obtain additional information regarding the content of the V. cholerae genome, suppression subtractive hybridization (SSH) was used to prepare libraries of DNA sequences from two southern California coastal isolates which are divergent or absent in the clinical strain V. cholerae O1 El Tor N16961. More than 1,400 subtracted clones were sequenced. This revealed the presence of novel sequences encoding functions related to cell surface structures, transport, metabolism, signal transduction, luminescence, mobile elements, stress resistance, and virulence. Flanking sequence information was determined for loci of interest, and the distribution of these sequences was assessed for a collection of V. cholerae strains obtained from southern California and Mexican environments. This led to the surprising observation that sequences related to the toxin genes toxA, cnf1, and exoY are widespread and more common in these strains than those of the cholera toxin genes which are a hallmark of the pandemic strains of V. cholerae. Gene transfer among these strains could be facilitated by a 4.9-kbp plasmid discovered in one isolate, which possesses similarity to plasmids from other environmental vibrios. By investigating some of the nucleotide sequence basis for V. cholerae genotypic diversity, DNA fragments have been uncovered which could promote survival in coastal environments. Furthermore, a set of genes has been described which could be involved in as yet undiscovered interactions between V. cholerae and eukaryotic organisms.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.