ArticleThe Journal of experimental medicine2005
Gammadelta T cell-induced hyaluronan production by epithelial cells regulates inflammation.
Article in The Journal of experimental medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 92 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
92 citing papers in PubMed, 160 citations in OpenAlex.
- Ligand-dependent Wnt signaling promotes gastric cancer metastasis through hyaluronan expression in microenvironment.Nature communications · 2026Article
- Spatiotemporal dynamics of mammalian wound healing.Cell discovery · 2026Review
- Functional heterogeneity of γδ T cells in colorectal cancer.Frontiers in immunology · 2026Review
- TNFR2 is expressed by a discrete subset of epidermal T cells with an IL-17 gene signature during psoriasis.PloS one · 2026Article
- Bioinspired honeycomb-mimetic adaptive hyaluronic acid hydrogel composite scaffold: intelligent prevention and treatment of infection of bone implants and promotion of bone repair.Materials today. Bio · 2025Article
- Review
- TNFR2 is Expressed by a Discrete Subset of Epidermal γδ T Cells with an IL-17 Gene Signature during Psoriasis.bioRxiv : the preprint server for biology · 2025Article
- Skin Resident T Cell Interactions with NPY1RbioRxiv : the preprint server for biology · 2025Article
- Exploring machine learning strategies for single-cell transcriptomic analysis in wound healing.Burns & trauma · 2025Review
- Intestinal CD8+ γδ T cells shift from immune activation to suppression, with concomitant impairment of cytotoxicity as disease activity increases in patients with ulcerative colitis.Central-European journal of immunology · 2025Article
- Roles of dendritic epidermal T cells in steady and different pathological states.Burns & trauma · 2025Review
- Primordial Cells Bridging the Gap Between Innate and Adaptive Immunity.Advances in experimental medicine and biology · 2025Review
- Cellular and molecular mechanisms of skin wound healing.Nature reviews. Molecular cell biology · 2024Review
- Role of the Skin Immune System in Wound Healing.Cells · 2024Review
- Wound-Induced Hair Follicle Neogenesis as a Promising Approach for Hair Regeneration.Molecules and cells · 2023Review
- T cells in health and disease.Signal transduction and targeted therapy · 2023Review
- Hyaluronan and Reactive Oxygen Species Signaling-Novel Cues from the Matrix?Antioxidants (Basel, Switzerland) · 2023Review
- Keratinoctye-neuro-immune-units (KNICUs): collaborative impact on the initiation and maintenance of psoriasis.Frontiers in medicine · 2023Review
- Acute Inflammation in Tissue Healing.International journal of molecular sciences · 2022Review
- Real-time imaging of inflammation and its resolution: It's apparent because it's transparent.Immunological reviews · 2022Review
32 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
Nonhealing wounds are a major complication of diseases such as diabetes and rheumatoid arthritis. For efficient tissue repair, inflammatory cells must infiltrate into the damaged tissue to orchestrate wound closure. Hyaluronan is involved in the inflammation associated with wound repair and binds the surface of leukocytes infiltrating damaged sites. Skin gammadelta T cells play specialized roles in keratinocyte proliferation during wound repair. Here, we show that gammadelta T cells are required for hyaluronan deposition in the extracellular matrix (ECM) and subsequent macrophage infiltration into wound sites. We describe a novel mechanism of control in which gammadelta T cell-derived keratinocyte growth factors induce epithelial cell production of hyaluronan. In turn, hyaluronan recruits macrophages to the site of damage. These results demonstrate a novel function for skin gammadelta T cells in inflammation and provide a new perspective on T cell regulation of ECM molecules.
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Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.