Evidence map›Paper›PMID 15837808›Full record

ArticleGenome research2005

Retroviruses and yeast retrotransposons use overlapping sets of host genes.

Becky Irwin, Michael Aye, Pierre Baldi, Nadejda Beliakova-Bethell, Henry Cheng, Yimeng Dou, Willy Liou, Suzanne Sandmeyer

Abstract readComparative Study
In one paragraph

Article in Genome research, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 62 papers.

0numbers the graph read from it
0cells of the map it votes in
62citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

62 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Artificial optimization of bambooFrontiers in plant science · 2022
    Article
  5. Article
  6. CoelacanthJournal of virology · 2021
    Article
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Review
  20. DNA double-strand break repair in Penaeus monodon is predominantly dependent on homologous recombination.DNA research : an international journal for rapid publication of reports on genes and genomes · 2017
    Article

2 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Becky IrwinDepartment of Biological Chemistry, University of California-Irvine, Irvine, CA 92697, USA.
Michael Aye
Pierre Baldi
Nadejda Beliakova-Bethell
Henry Cheng
Yimeng Dou
Willy Liou
Suzanne Sandmeyer

Funding

Biomedical Informatics Training ProgramT15LM007443 · NLM · UNIVERSITY OF CALIFORNIA-IRVINE · PI BALDI, PIERRE · 2002 to 2012
$9.3M
Ty3 Viruslike Particle Morphogenesis and Host InteractionsR01GM033281 · NIGMS · UNIVERSITY OF CALIFORNIA-IRVINE · PI SANDMEYER, SUZANNE · 1985 to 2013
$4.7M
NIGMS NIH HHS GM 33281NIGMS NIH HHS R01 GM033281NLM NIH HHS 5T15 LM 007443NLM NIH HHS T15 LM007443
6 · The paper itself

Abstract

A collection of 4457 Saccharomyces cerevisiae mutants deleted for nonessential genes was screened for mutants with increased or decreased mobilization of the gypsylike retroelement Ty3. Of these, 64 exhibited increased and 66 decreased Ty3 transposition compared with the parental strain. Genes identified in this screen were grouped according to function by using GOnet software developed as part of this study. Gene clusters were related to chromatin and transcript elongation, translation and cytoplasmic RNA processing, vesicular trafficking, nuclear transport, and DNA maintenance. Sixty-six of the mutants were tested for Ty3 proteins and cDNA. Ty3 cDNA and transposition were increased in mutants affected in nuclear pore biogenesis and in a subset of mutants lacking proteins that interact physically or genetically with a replication clamp loader. Our results suggest that nuclear entry is linked mechanistically to Ty3 cDNA synthesis but that host replication factors antagonize Ty3 replication. Some of the factors we identified have been previously shown to affect Ty1 transposition and others to affect retroviral budding. Host factors, such as these, shared by distantly related Ty retroelements and retroviruses are novel candidates for antiviral targets.

Indexed as

Blotting, SouthernChromatinComputational BiologyDNA, ComplementaryDNA Mutational AnalysisFungal ProteinsGene Expression Regulation, FungalIntegration Host FactorsMutationNuclear PoreRetroelementsSaccharomyces cerevisiaeSchizosaccharomycesTranscription, GeneticChromatinDNA, ComplementaryFungal ProteinsIntegration Host FactorsRetroelements

Identifiers

PMID15837808
PMCPMC1088292

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.