ArticleThe Journal of cell biology2005
p90Rsk is not involved in cytostatic factor arrest in mouse oocytes.
Article in The Journal of cell biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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Who cites it
30 citing papers in PubMed.
- Identification and Characterization ofBiomolecules · 2023Article
- ERK1/2-RSK2 Signaling in Regulation of ERα-Mediated Responses.Endocrinology · 2022Review
- Ras/ERK-signalling promotes tRNA synthesis and growth via the RNA polymerase III repressor Maf1 in Drosophila.PLoS genetics · 2018Article
- Animal Models for Coffin-Lowry Syndrome: RSK2 and Nervous System Dysfunction.Frontiers in behavioral neuroscience · 2018Review
- Emi2 Is Essential for Mouse Spermatogenesis.Cell reports · 2017Article
- Peritoneal and hematogenous metastases of ovarian cancer cells are both controlled by the p90RSK through a self-reinforcing cell autonomous mechanism.Oncotarget · 2016Article
- Vertebrate Reproduction.Cold Spring Harbor perspectives in biology · 2015Review
- Regulation of NHE3 by lysophosphatidic acid is mediated by phosphorylation of NHE3 by RSK2.American journal of physiology. Cell physiology · 2015Article
- RSK promotes G2/M transition through activating phosphorylation of Cdc25A and Cdc25B.Oncogene · 2014Article
- Release from meiotic arrest in ascidian eggs requires the activity of two phosphatases but not CaMKII.Development (Cambridge, England) · 2013Article
- Modulation of cell cycle control during oocyte-to-embryo transitions.The EMBO journal · 2013Review
- Cdc25A activity is required for the metaphase II arrest in mouse oocytes.Journal of cell science · 2013Article
- Identification of germ cell-specific genes in mammalian meiotic prophase.BMC bioinformatics · 2013Article
- A zinc-dependent mechanism regulates meiotic progression in mammalian oocytes.Biology of reproduction · 2012Article
- Phosphorylation of eukaryotic translation initiation factor 4B (EIF4B) by open reading frame 45/p90 ribosomal S6 kinase (ORF45/RSK) signaling axis facilitates protein translation during Kaposi sarcoma-associated herpesvirus (KSHV) lytic replication.The Journal of biological chemistry · 2011Article
- p90RSK2 is essential for FLT3-ITD- but dispensable for BCR-ABL-induced myeloid leukemia.Blood · 2011Article
- Activation and function of the MAPKs and their substrates, the MAPK-activated protein kinases.Microbiology and molecular biology reviews : MMBR · 2011Review
- Article
- Mos in the oocyte: how to use MAPK independently of growth factors and transcription to control meiotic divisions.Journal of signal transduction · 2011Article
- A genome-wide RNAi screen identifies multiple RSK-dependent regulators of cell migration.Genes & development · 2010Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vertebrate oocytes arrest in metaphase of the second meiotic division (MII), where they maintain a high cdc2/cyclin B activity and a stable, bipolar spindle because of cytostatic factor (CSF) activity. The Mos-MAPK pathway is essential for establishing CSF. Indeed, oocytes from the mos-/- strain do not arrest in MII and activate without fertilization, as do Xenopus laevis oocytes injected with morpholino oligonucleotides directed against Mos. In Xenopus oocytes, p90Rsk (ribosomal S6 kinase), a MAPK substrate, is the main mediator of CSF activity. We show here that this is not the case in mouse oocytes. The injection of constitutively active mutant forms of Rsk1 and Rsk2 does not induce a cell cycle arrest in two-cell mouse embryos. Moreover, these two mutant forms do not restore MII arrest after their injection into mos-/- oocytes. Eventually, oocytes from the triple Rsk (1, 2, 3) knockout present a normal CSF arrest. We demonstrate that p90Rsk is not involved in the MII arrest of mouse oocytes.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.