ArticleJournal of general internal medicine2005
Barriers to translating emerging genetic research on smoking into clinical practice. Perspectives of primary care physicians.
Article in Journal of general internal medicine, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Guidelines for genetic risk assessment of hereditary breast and ovarian cancer: early disagreements and low utilization.Journal of general internal medicine · 2009Guideline
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- Physicians' Knowledge and Attitudes Regarding Point-of-Care Pharmacogenetic Testing: A Hospital-Based Cross-Sectional Study.Pharmacogenomics and personalized medicine · 2021Article
- The Use of the Nicotine Metabolite Ratio as a Biomarker to Personalize Smoking Cessation Treatment: Current Evidence and Future Directions.Cancer prevention research (Philadelphia, Pa.) · 2020Review
- Ethiopian health care professionals' knowledge, attitude, and interests toward pharmacogenomics.Pharmacogenomics and personalized medicine · 2017Article
- Pharmacogenetic approaches in the treatment of alcohol use disorders: addressing clinical utility and implementation thresholds.Addiction science & clinical practice · 2014Review
- Pilot study of pharmacist-assisted delivery of pharmacogenetic testing in a primary care setting.Pharmacogenomics · 2014Article
- Physicians' attitudes about multiplex tumor genomic testing.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2014Article
- Bumps along the translational pathway: anticipating uptake of tailored smoking cessation treatment.Personalized medicine · 2013Article
- Genes, race, and culture in clinical care: racial profiling in the management of chronic illness.Medical anthropology quarterly · 2013Article
- Primary care physicians' knowledge of and experience with pharmacogenetic testing.Clinical genetics · 2012Article
- Delivering a pharmacogenetic service: is there a role for genetic counselors?Journal of genetic counseling · 2012Article
- Survey of US public attitudes toward pharmacogenetic testing.The pharmacogenomics journal · 2012Article
- Knowledge, attitudes and preferences regarding genetic testing for smoking cessation. A cross-sectional survey among Dutch smokers.BMJ open · 2012Article
- Characterization of clinical study populations by race and ethnicity in biomedical literature.Ethnicity & disease · 2012Article
- Biomarkers to optimize the treatment of nicotine dependence.Biomarkers in medicine · 2011Review
- Why is genetic screening for autosomal dominant disorders underused in families? The case of hereditary hemorrhagic telangiectasia.Genetics in medicine : official journal of the American College of Medical Genetics · 2011Article
- Genomic risk profiling: attitudes and use in personal and clinical care of primary care physicians who offer risk profiling.Journal of general internal medicine · 2011Article
- Ethical concerns related to developing pharmacogenomic treatment strategies for addiction.Addiction science & clinical practice · 2011Article
- Physician barriers to incorporating pharmacogenetic treatment strategies for nicotine dependence into clinical practice.Clinical pharmacology and therapeutics · 2011Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
objectiveSmoking remains the leading cause of preventable death nationally. Emerging research may lead to improved smoking cessation treatment options, including tailoring treatment by genotype. Our objective was to assess primary care physicians' attitudes toward new genetic-based approaches to smoking treatment. DESIGN AND
settingA 2002 national survey of primary care physicians. Respondents were randomly assigned a survey including 1 of 2 scenarios: a scenario in which a new test to tailor smoking treatment was described as a "genetic" test or one in which the new test was described as a "serum protein" test.
participantsThe study sample was randomly drawn from all U.S. primary care physicians in the American Medical Association Masterfile (e.g., those with a primary specialty of internal medicine, family practice, or general practice). Of 2,000 sampled physicians, 1,120 responded, yielding a response rate of 62.3%. MEASUREMENTS AND MAIN
resultsControlling for physician and practice characteristics, describing a new test as "genetic" resulted in a regression-adjusted mean adoption score of 73.5, compared to a score of 82.5 for a nongenetic test, reflecting an 11% reduction in physicians' likelihood of offering such a test to their patients.
conclusionsMerely describing a new test to tailor smoking treatment as "genetic" poses a significant barrier to physician adoption. Considering national estimates of those who smoke on a daily basis, this 11% reduction in adoption scores would translate into 3.9 million smokers who would not be offered a new genetic-based treatment for smoking. While emerging genetic research may lead to improved smoking treatment, the potential of novel interventions will likely go unrealized unless barriers to clinical integration are addressed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.