ArticleThe Journal of membrane biology2005
A mathematical model of electrolyte and fluid transport across corneal endothelium.
Article in The Journal of membrane biology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 55 citations in OpenAlex.
- A mathematical model of corneal endothelium pump function.Journal of the Royal Society, Interface · 2025Article
- Tissue engineering of the corneal endothelium: a review of carrier materials.Journal of functional biomaterials · 2013Article
- Transient swelling, spreading, and drug delivery by a dissolved anti-HIV microbicide-bearing film.Physics of fluids (Woodbury, N.Y. : 1994) · 2013Article
- Biophysical model of ion transport across human respiratory epithelia allows quantification of ion permeabilities.Biophysical journal · 2013Article
- Mathematical properties of pump-leak models of cell volume control and electrolyte balance.Journal of mathematical biology · 2012Article
- Transient spreading and swelling behavior of a gel deploying an anti-HIV topical microbicide.Journal of non-Newtonian fluid mechanics · 2012Article
- Molecular bioelectricity in developmental biology: new tools and recent discoveries: control of cell behavior and pattern formation by transmembrane potential gradients.BioEssays : news and reviews in molecular, cellular and developmental biology · 2012Review
- Regulation of cell behavior and tissue patterning by bioelectrical signals: challenges and opportunities for biomedical engineering.Annual review of biomedical engineering · 2012Review
- Osmoregulation and epithelial water transport: lessons from the intestine of marine teleost fish.Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology · 2012Review
- The plasma membrane potential and the organization of the actin cytoskeleton of epithelial cells.International journal of cell biology · 2012Article
- Oxygen-deficient metabolism and corneal edema.Progress in retinal and eye research · 2011Article
- Comparative permeabilities of the paracellular and transcellular pathways of corneal endothelial layers.The Journal of membrane biology · 2011Article
- Frequency spectrum of transepithelial potential difference reveals transport-related oscillations.Biophysical journal · 2009Article
- Bioelectric mechanisms in regeneration: Unique aspects and future perspectives.Seminars in cell & developmental biology · 2009Review
- Functions of aquaporins in the eye.Progress in retinal and eye research · 2008Review
- Fluid transport: a guide for the perplexed.The Journal of membrane biology · 2008Review
- Corneal endothelium transports fluid in the absence of net solute transport.Biochimica et biophysica acta · 2007Article
- Modulation of tight junction properties relevant to fluid transport across rabbit corneal endothelium.Experimental eye research · 2007Article
- The Role of the Tight Junction in Paracellular Fluid Transport across Corneal Endothelium. Electro-osmosis as a Driving Force.The Journal of membrane biology · 2006Review
- Aquaporins and CFTR in ocular epithelial fluid transport.The Journal of membrane biology · 2006Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
To predict the behavior of a transporting epithelium by intuitive means can be complex and frustrating. As the number of parameters to be considered increases beyond a few, the task can be termed impossible. The alternative is to model epithelial behavior by mathematical means. For that to be feasible, it has been presumed that a large amount of experimental information is required, so as to be able to use known values for the majority of kinetic parameters. However, in the present case, we are modeling corneal endothelial behavior beginning with experimental values for only five of eleven parameters. The remaining parameter values are calculated assuming cellular steady state and using algebraic software. With that as base, as in preceding treatments but with a distribution of channels/transporters suited to the endothelium, temporal cell and tissue behavior are computed by a program written in Basic that monitors changes in chemical and electrical driving forces across cell membranes and the paracellular pathway. We find that the program reproduces quite well the behaviors experimentally observed for the translayer electrical potential difference and rate of fluid transport, (a) in the steady state, (b) after perturbations by changes in ambient conditions HCO3-, Na+, and Cl- concentrations), and (c) after challenge by inhibitors (ouabain, DIDS, Na+- and Cl(-)-channel inhibitors). In addition, we have used the program to compare predictions of translayer fluid transport by two competing theories, electro-osmosis and local osmosis. Only predictions using electro-osmosis fit all the experimental data.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.