Evidence map›Paper›PMID 15834650›Full record

ArticleJournal of neurology2005

Release of brain-type and heart-type fatty acid-binding proteins in serum after acute ischaemic stroke.

Michael T Wunderlich, Thorsten Hanhoff, Michael Goertler, Friedrich Spener, Jane F C Glatz, Claus-W Wallesch, Maurice M A L Pelsers

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Journal of neurology, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 1 pooled it
1.5field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.

  1. Pooled it
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  5. H-FABP as a Biomarker in Transient Ischemic Attack.Journal of cardiovascular translational research · 2025
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Michael T WunderlichDept. of Neurology, University of Magdeburg, Leipziger Strasse 44, 39120 Magdeburg, Germany. michael.wunderlich@medizin.unimagdeburg.de
Thorsten Hanhoff
Michael Goertler
Friedrich Spener
Jane F C Glatz
Claus-W Wallesch
Maurice M A L Pelsers
University Hospital Magdeburg · DEMaastricht University · NLUniversity of Münster · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study aimed at an analysis of the release of Braintype and Heart-type Fatty Acid- Binding Proteins (B-FABP and HFABP) in acute ischaemic stroke and their potential value as neurobiochemical markers of brain damage. We investigated 42 consecutive patients admitted within 6 hours after ischaemic stroke. Serial venous blood samples were taken hourly between 1 to 6 hours, and at 12, 18, 24, 48, 72, 96, and 120 hours after stroke onset. In all patients lesion topography was assessed and infarct volume was calculated. The neurological deficit was quantified by the National Institutes of Health stroke scale score, and functional outcome was assessed with the modified Rankin Scale 3 months after stroke. H-FABP and B-FABP concentrations showed peak values already 2 to 3 hours after stroke onset and remained elevated up to last measurements at 120 hours.Unlike BFABP, early H-FABP concentrations were significantly associated with the severity of the neurological deficit and the functional outcome. High H-FABP release was associated with large infarction on CT. Our study shows for the first time quantitative data of serum BFABP and H-FABP being elevated early in acute ischaemic stroke indicating that especially H-FABP might have the potential to be a rapid marker of brain damage and clinical severity. As both FABPs indicate damage to neuronal and glial tissue but are not specific for cerebral infarction, further investigations are needed to better understand the prolonged release of both in ischaemic stroke which is in contrast to the transient increase after myocardial infarction and can not be explained by their renal extraction.

Indexed as

AdolescentAdultAgedBrainBrain InfarctionCarrier ProteinsEnzyme-Linked Immunosorbent AssayFatty Acid Binding Protein 3Fatty Acid-Binding ProteinsFemaleHumansMaleMiddle AgedMyocardiumStatistics as TopicStrokeCarrier ProteinsFABP3 protein, humanFatty Acid Binding Protein 3Fatty Acid-Binding Proteins

Identifiers

PMID15834650
OpenAlexW2019489057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.