ArticleGenetics2005
Behavioral degradation under mutation accumulation in Caenorhabditis elegans.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed.
- Bee swimming is adaptive but disrupted by insecticide.Communications biology · 2026Article
- Multigenerational downregulation of insulin/IGF-1 signaling in adulthood improves lineage survival, reproduction, and fitness in Caenorhabditis elegans supporting the developmental theory of ageing.Evolution; international journal of organic evolution · 2022Article
- Analyzing the Response Behavior ofInternational journal of environmental research and public health · 2020Article
- Males, Outcrossing, and Sexual Selection inGenetics · 2019Review
- Hierarchical Assessment of Mutation Properties inG3 (Bethesda, Md.) · 2018Article
- Increase in viability due to the accumulation of X chromosome mutations in Drosophila melanogaster males.Genetica · 2018Article
- The mutational structure of metabolism in Caenorhabditis elegans.Evolution; international journal of organic evolution · 2016Article
- Fitness Effects of Spontaneous Mutations in Picoeukaryotic Marine Green Algae.G3 (Bethesda, Md.) · 2016Article
- Mutation and Human Exceptionalism: Our Future Genetic Load.Genetics · 2016Article
- Mainstreaming Caenorhabditis elegans in experimental evolution.Proceedings. Biological sciences · 2014Review
- Temporal dynamics of outcrossing and host mortality rates in host-pathogen experimental coevolution.Evolution; international journal of organic evolution · 2013Article
- Genetic (Co)variation for life span in rhabditid nematodes: role of mutation, selection, and history.The journals of gerontology. Series A, Biological sciences and medical sciences · 2009Article
- Analysis and implications of mutational variation.Genetica · 2009Review
- Article
- Selection against males in Caenorhabditis elegans under two mutational treatments.Proceedings. Biological sciences · 2007Article
- Low impact of germline transposition on the rate of mildly deleterious mutation in Caenorhabditis elegans.Genetics · 2006Article
- Cumulative effects of spontaneous mutations for fitness in Caenorhabditis: role of genotype, environment and stress.Genetics · 2006Article
- Spontaneous mutational correlations for life-history, morphological and behavioral characters in Caenorhabditis elegans.Genetics · 2005Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Spontaneous mutations play a fundamental role in the maintenance of genetic variation in natural populations, the nature of inbreeding depression, the evolution of sexual reproduction, and the conservation of endangered species. Using long-term mutation-accumulation lines of the nematode Caenorhabditis elegans, we estimate the rate and magnitude of mutational effects for a suite of behaviors characterizing individual chemosensory responses to a repellant stimulus. In accordance with evidence that the vast majority of mutations are deleterious, we find that behavioral responses degrade over time as a result of spontaneous mutation accumulation. The rate of mutation for behavioral traits is roughly of the same order or slightly smaller than those previously estimated for reproductive traits and the average size of the mutational effects is also comparable. These results have important implications for the maintenance of genetic variation for behavior in natural populations as well as for expectations for behavioral change within endangered species and captive populations.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.