ArticleGenetics2005
Spontaneous mutational correlations for life-history, morphological and behavioral characters in Caenorhabditis elegans.
Article in Genetics, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
33 citing papers in PubMed.
- Life history in Caenorhabditis elegans: from molecular genetics to evolutionary ecology.Genetics · 2024Review
- The evolution of genetic covariance and modularity as a result of multigenerational environmental fluctuation.Evolution letters · 2023Article
- Microbes are potential key players in the evolution of life histories and aging inEcology and evolution · 2023Article
- Article
- Causes of variability in estimates of mutational variance from mutation accumulation experiments.Genetics · 2022Article
- Integrating genomics and multivariate evolutionary quantitative genetics: a case study of constraints on sexual selection inProceedings. Biological sciences · 2021Article
- The contribution of mutation and selection to multivariate quantitative genetic variance in an outbred population ofProceedings of the National Academy of Sciences of the United States of America · 2021Article
- Hormonal pleiotropy structures genetic covariance.Evolution letters · 2021Article
- Correlational selection in the age of genomics.Nature ecology & evolution · 2021Review
- Deleterious mutations show increasing negative effects with age in Drosophila melanogaster.BMC biology · 2020Article
- A large close relative of C. elegans is slow-developing but not long-lived.BMC evolutionary biology · 2019Article
- Hierarchical Assessment of Mutation Properties inG3 (Bethesda, Md.) · 2018Article
- Article
- Network Architecture and Mutational Sensitivity of theFrontiers in molecular biosciences · 2018Article
- Article
- Epistasis and Pleiotropy Affect the Modularity of the Genotype-Phenotype Map of Cross-Resistance in HIV-1.Molecular biology and evolution · 2016Article
- The mutational structure of metabolism in Caenorhabditis elegans.Evolution; international journal of organic evolution · 2016Article
- The role of hermaphrodites in the experimental evolution of increased outcrossing rates in Caenorhabditis elegans.BMC evolutionary biology · 2014Article
- Mainstreaming Caenorhabditis elegans in experimental evolution.Proceedings. Biological sciences · 2014Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
The pattern of mutational covariance among traits plays a central, but largely untested, role in many theories in evolutionary genetics. Here we estimate the pattern of phenotypic, environmental, and mutational correlations for a set of life-history, behavioral, and morphological traits using 67 self-fertilizing lines of Caenorhabditis elegans, each having independently experienced an average of 370 generations of spontaneous mutation accumulation. Bivariate relationships of mutational effects indicate the existence of extensive pleiotropy. We find that mutations may tend to produce manifold effects on suites of functionally related traits; however, our data do not support the idea of completely parcelated pleiotropy, in which functional units are separately affected by mutations. Positive net phenotypic and mutational correlations are common for life-history traits, with environmental correlations being comparatively smaller and of the same sign for most pairs of traits. Observed mutational correlations are shown to be higher than those produced by the chance accumulation of nonpleiotropic mutations in the same lines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.